Antiplatelet agents

Question 1

MOA of aspirin?

Answer 1

Inhibition of platelet COX-1 (irreversible)

Question 2

What 4 drugs platelet ADP (P2Y12) receptors?

Which are reversible? Irreversible?

Answer 2

Ticagrelor - reversible

Clopidogrel and Prasugrel - irreversible.

Question 3

MOA of dipyridamole?

Answer 3

Inhibits phosphodiesterase in plateles, increasing cAMP, which increases PGI2 causing an anti-aggregation effect

Question 4

MOA of abciximab, eptifibatide, and tirofiban?

Answer 4

Blocks platelet GIIb and IIIa receptor, preventing fibrinogen binding and platelet aggregation.
Abciximab works via monoclonal antibody
Eptifibatide works via cyclic peptide
Tirofiban works via non-peptide

Question 5

What platelet ADP receptor inhibitor is less efficacious than the others?

Answer 5

Clopidogrel is less efficacious than ticagrelor or prasugrel.

Question 6

Onset of action of aspirin?

Answer 6

rapid

Question 7

Onset of action of ticagrelor, clopidogrel, and prasugrel?

Answer 7

2 hours

Question 8

Elimination of aspirin?

Answer 8

Hepatic

Question 9

Elimination of clopidogrel?

Answer 9

Renal and fecal excretion

Question 10

Elimination of dipyridamole?

Answer 10

Hepatic phase II conjugation

Question 11

Adverse reactions to aspirin?

Answer 11

Gastric upset

Bleeding

Question 12

DDI occur between clopidogrel and ?

Answer 12

PPIs

Question 13

Uses for aspirin?

Answer 13

Acute MI, Unstable angina, PCI, secondary prevention of MI/stroke

Question 14

Uses for clopidogrel?

Answer 14

Acute MI, unstable angina, PCI

Question 15

Uses for dipyridamole?

Answer 15

Secondary prevention of MI/stroke