Antiviral agents

Question 1

What medications are neuraminidase inhibitors?

Answer 1

Oseltamivir

Zanamivir

Question 2

What antivirals can be used to treat Influenza?

Answer 2

Oseltamivir
Zanamivir
Peramivir (off label)

Question 3

How are the following antivirals absorbed?
Oseltamivir
Zanamivir
Peramivir

Answer 3

Oseltamivir - orally as prodrug
Zanamivir - inhalation
Peramivir - IV infusion

Question 4

Elimination of Oseltamivir, Zanamivir, Peramivir?

Answer 4

Renal

Question 5

Adverse reactions to oseltamivir?

Answer 5

N/V, abd pain

Question 6

Adverse reactions to zanamivir?

Answer 6

Cough, bronchospasm

Question 7

Mechanism of action for baloxavir?

Answer 7

Selective inhibition of cap-dependent endonuclease, blocking mRNA transcription.

Question 8

Clinical use of baloxavir?

Answer 8

Influenza A and B

Question 9

Elimination of baloxavir?

Answer 9

Biliary-fecal excretion

Question 10

Amantadine and rimantadine mechanism?

Answer 10

Blocks H+ ion chanel preventing pH change necessary for uncoating.

Question 11

Elimination of amantadine and rimantadine?

Answer 11

Amantadine - renal

Rimantadine -heaptic

Question 12

Clinical uses of amantadine and rimantadine?

Answer 12

No current antiviral use due to resistance

Question 13

Anti- herpes meds?

Answer 13

Acyclovir and its analogs