IM Rheumatology Flashcards
What three drugs are approved to treat fibromyalgia?
Duloxetine, milnacipran, and pregabalin
What does synovial fluid analysis show in gout?
Rod shaped negatively birefringent sodium urate crystals
What is the treatment for an acute gout flare?
Indomethacin TID, colchicine.
What are common side effects of colchicine?
Diarrhea, GI upset
What medications can trigger a gout flare?
Thiazide diuretics, aspirin
What medication is used to prevent gout flares?
Allopurinol
What is the most common joint affected by pseudogout?
Knees
What does synovial fluid analysis show in pseudogout?
Rhomboid-shaped weakly positively birefringent calcium pyrophosphate crystals.
What is the treatment for acute psuedogout flares?
NSAIDs
What is the prophylactic treatment for pseudogout?
Colchicine
Polyarteritis nodosa is characterized by inflammation of what sized arteries?
Small and medium
Describe the typical polyarteritis nodosa patient?
40-50 year old men
What antibody is highly associated with polymyositis?
Anti Jo-1
What autoantibody is highly sensitive for SLE?
Which are highly specific?
ANA is sensitive, not specific.
Anti-dsDNA and anti-Smith are specific but not sensitive
What antibody is highly associated with scleroderma (limited disease)?
Anticentromere antibody
What antibody is highly specific for diffuse scleroderma?
Anti-topoisomerase I (Anti-Scl70)
What antibodies are highly specific for Sjogren syndrome?
Anti-Ro (SSA) or anti-La (SSB)
What test is used to diagnose Sjogren’s?
Schirmer test
Patients with Sjogrens are at higher risk for developing what type of cancer?
Lymphoma
What types of infections can trigger reactive arthritis?
GU or GI infections
What autoantibody is associated with drug-induced lupus?
Anti histone antibody.
Describe the deformities in the hand caused by rheumatoid arthritis.
Swelling in bilateral MCPs, PIPs, ulnar deviation at MCP, boutonniere deformity, swan neck deformity
What rheumatology labs are positive in rheumatoid arthritis?
RF or Anti-CCP
What rash is pathognomonic for polyarteritis nodosa?
Starburst livedo
