Labs of GI

Question 1

Important protein produced by the liver?

Answer 1

Albumin

Question 2

LFT’s

Answer 2

Albumin, prealbumin, prothrombin

Question 3

Function of albumin?

Answer 3

Transports hormones and chemicals

Maintains plasma oncotic pressure*** (important)

Question 4

What symptoms does hypoalbuminemia cause?

Answer 4

Fluid leaks into interstitial spaces - edema, ascites

Question 5

Prealbumin is another measure of liver function. It is ____ sensitive to protein intake than albumin

Answer 5

More

Question 6

Uses of prealbumin?

Answer 6

Liver function

Nutritional status

Question 7

How to calculate total protein?

Answer 7

Albumin plus globulin

Question 8

What does globulin measure?

Answer 8

Total immunoglobulins in serum

Question 9

T/F? Globulin is synthesized by the liver.

Answer 9

False

Question 10

How to calculate globulin?

Answer 10

Total protein - albumin

Question 11

When is total protein useful?

Answer 11

Assessing immune or hematologic dysfunction

Question 12

What does prothrombin time measure?

Answer 12

Extrinsic coagulation pathway

Question 13

Normal range for PT?

Answer 13

10-13 seconds

Question 14

What is INR?

Answer 14

International normalized ratio

It normalizes PT for lab variations

Question 15

Normal range for INR?

Answer 15

1-2

Question 16

How much loss of function of the liver before PT becomes prolonged?

Answer 16

substantial >80%

Question 17

is aPTT dependent on liver function?

Answer 17

No

Question 18

PTINR used for monitoring _____ therapy

Answer 18

Coumadin

Question 19

aPTT used for monitoring _____ therapy

Answer 19

heparin

Question 20

Liver enzymes in LFTs?

Answer 20

ALP, AST, ALT, LFH, GGT

Question 21

Elevations of ALP >4x normal limit is suggestive of ______

Answer 21

cholestasis

Question 22

When evaluating an elevated ALP, why is GGT helpful?

Answer 22

ALP elevation with GTT elevation is from a hepatic cause

ALP elevation with normal GGT is a non hepatic cause

Question 23

GGT can also be used to monitor

Answer 23

Abstinence from alcohol

Question 24

AST elevations without ALT elevations suggest ____ source

Answer 24

Cardiac

Question 25

Expected AST/ALT ratio in alcoholic liver disease?

Hepatitis?

Answer 25

Alcoholic liver disease - >1

Hepatitis - <1

Question 26

Jaundice is a hallmark sign of

Answer 26

Elevated bilirubin

Question 27

Tumor marker for hepatocellular carincoma?

Answer 27

Alpha fetoprotein

Question 28

What lab is stupid high in pancreatitis?

Answer 28

Amylase - can be up to 20k

Normal is 44-128

Question 29

What other lab is high in pancreatitis?

Answer 29

Lipase

Question 30

What rises first in pancreatitis? Amylase or lipase?

What goes down first?

Answer 30

amylase goes up first and down first

Question 31

How long does amylase take to rise and peak?

Answer 31

Rises 2-6 hours of onset

Peaks 20-30 hours after onset

Question 32

Function of lipase?

Answer 32

Fat digestion

Question 33

Tumor marker for colorectal carincomas?

Answer 33

CEA