Cholinergic agonists Flashcards
What cholinergic agonists directly act on muscarinic receptors?
Pilocarpine and Bethanechol
What drugs are intermediate-long acting indirect cholinergic agonists?
Neostigmine and Physotigmine
What drugs are short acting indirect cholinergic agonists?
Edrophonium and Donepezil
How long does organophosphate poisoning last?
Very long
What effect do cholinergic agonists have on the heart? What receptor do they act on?
Decrease rate, contractility, and conduction.
M2 receptors
What effect do cholinergic agonists have on blood vessels?
What receptor do they act on?
Vasodilation
M3 receptors
What effect do cholinergic agonists have on blood pressure?
What receptor do they act on?
Hypotension
M3 receptors
What effect do cholinergic agonists have on the lungs?
What receptor do they act on?
Bronchoconstriction and increase secretions
M3 receptors
What effect do cholinergic agonists have on temperature regulation?
What receptor do they act on?
Increased sweating causes heat loss
M3 receptors
What effect do cholinergic agonists have on the eyes?
What receptor do they act on?
Miosis (constriction)
Accommodation for near focus
Increase aqueous humor outflow
M3 receptors.
What effect do cholinergic agonists have on the GI/GU system?
What receptor do they act on?
Increase salivation (xerostomia)
Increase detrusor muscle contraction
Increase GI motility
M3 receptors
What effect do cholinergic agonists have on the CNS?
What receptor do they act on?
Improve memory, cognition, and movement
M1 receptor
What effect do cholinergic agonists have on the NMJ?
What receptor do they act on?
Muscle contraction
Nicotinic receptors
