Cholinergic Antagonists Flashcards
What cholinergic antagonists are non-selective antimuscarinics?
Atropine, scopolamine, benztropine
Oxybutinin, tolterodine
Ipratropium, tiotropium
What cholinergic antagonists are neuromuscular blockers?
Atracurium, rocuronium, succinylcholine
Effects of cholinergic antagonists on the heart?
What receptor is acted on?
Increase heart rate
M2 receptors
Effects of cholinergic antagonists on blood vessels?
What receptor is acted on?
No effect
Effects of cholinergic antagonists on blood pressure?
What receptor is acted on?
Minimal effect on BP
M3 receptors
Effects of cholinergic antagonists on the lungs?
What receptor is acted on?
Bronchodilation, decrease secretions (drying)
M3 receptors
Effects of cholinergic antagonists on temperature regulation?
What receptor is acted on?
Increase body temperature
M3 receptors
Effects of cholinergic antagonists on the eyes?
What receptor is acted on?
Mydriasis, cycloplegia (loss of accommodation), decrease outflow of aqueous humor (increase IOP)
M3 receptors
Effects of cholinergic antagonists on the GI/GU system?
What receptor is acted on?
Decrease salivation, block detrusor contraction, decrease GI motility
M3 receptors
Effects of cholinergic antagonists on the CNS?
What receptor is acted on?
Sedation, confusion
M1 receptors
Effects of cholinergic antagonists on the NMJ?
What receptor is acted on?
Flaccid paralysis
Neuromuscular blockers