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Pharma > Parkinsonism > Flashcards

Parkinsonism Flashcards

1
Q

Antiparkinsonism drug that prevent peripheral conversion of L-Dopa to Dopamine?
Contraindication?

A

Levodopa-Carbidopa
Inhibit dopa decarboxylase
Contraindicated in patients with psychosis (may worsen)

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2
Q

Levodopa-Carbidopa + MAOI = ?

A

Hypertensive crisis

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3
Q

Differentiate on and off from wearing off

A

on and off: alternating improved mobility and akinesia

wearing off: progressive destruction of SNpc, deterioration of drug effect

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4
Q

Treatment for the two parkinsonian phenomena?

A

On and off Tx: Apomorphine (D3)

Wearing off Tx: Entacapone (COMT)

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5
Q

Partial agonist at D2 receptor (CNS) used in Parkinsons? Also used for hyperprolactinemia.

A

Bromocriptine

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6
Q

Side effect of bromocriptine due to episodic blood vessel blockade?

A

Erythromelalgia (burning pain and swelling of extremities)

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7
Q

Partial agonist at D3 in the CNS that causes compulsive gambling, hypersexuality, overeating and increased tendency to sleep?

A

Pramipexole

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8
Q

Pramipexole also used for?

A

Restless leg syndrome

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9
Q

Antiparkinsonism drug partial D3 agonist work during off periods of parkinsons that cause severe nausea?

A

Apomorphine

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10
Q

Severe nausea due to apomorphine prevented by premedication with?

A

Trimethobenzamine

“Tri-metoclopramide (antiemetic)”

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11
Q

Antiparkinsonism drug MAO-B inhibitor that decrease degradation of Dopamine in the CNS?

A

Selegeline

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12
Q

Selegeline + ___ is fatal = agitation, delirium, death

A

Meperidine

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13
Q

Selegeline + ___ = Serotonin syndrome FATCHD

A

SSRIs

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14
Q

COMT inhibitor used in wearing off that can cause neuroleptic malignant syndrome?

A

Entacapone

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15
Q

Neuroleptic malignant syndrome characterized by what symptoms? Antidote?

A

FEVER
Fever, Encephalopathy, VS unstable, Elevated CPK, Rigidity
Antidote: Dantrolene as in malig hyperther

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16
Q

Site of action of Entacapone and Tolcapone?

A

Entacapone - only in periphery

Tolcapone - both CNS and periphery, but more in CNS

17
Q

Antiviral drug also used for parkinsons?

May cause livedo reticularis

A

Amantadine
Also used in Influenza A only
(Oseltamivir for Influenza A and B)

18
Q

Drugs that cause livedo reticularis?

A

A man reads fHM and GQ

Amantadine, Hydroxyurea, Minocycline, Gemcitabine, Quinidine

19
Q

Antiparkinsonism drug also an anti-cholinergic that is used for EPS?

A

Benztropine (Park your Benz)

Exacerbate tardive dyskinesia

20
Q

Drug induced parkinsonism?

A

Typ antipsych
Reserpine
MPTP

Pharma (27 decks)

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