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Pharma > Antibiotics: Protein Syn Inhibitors > Flashcards

Antibiotics: Protein Syn Inhibitors Flashcards

0
Q

Concentration vs Time dependent?

A

CD: plasma level above MIC, more rapid and more proportion killed
(AG)
TD: directly related to time above when levels above MIC is reached
(Pen, ceph)

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1
Q

30s and 50s?

A

AT 30
Aminogly. Tetracyclines.
CELLS 50
Chloram. Eryth. Linezolid. Lincosamide. Streptogramins.

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2
Q

Effect seen in AG where killing action continues even at plasma concentration below measurable levels?

A

Post-antibiotic effect

Also in FQ

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3
Q

Greater efficacy of AG when taken in how many doses?

A

Single large dose
(Only given IM or IV)
Excreted renally, does NOT cross BBB

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4
Q

AG with narrowest therapeutic window?

A

Amikasin

Resistant to many enzymes

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5
Q

AG effective against anaerobes?

A

No. Need oxygen for uptake.

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6
Q

Examples of AG

A

STANG
Streptomycin/Spectinomycin, Tobramycin, Amikacin, Neomycin, Gentamicin
For infection by AEROBIC gram positive

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7
Q

Bactericidal aminoglycoside to 30s subunit used for endocarditis and ocular infections?

A

Gentamicin
Tobramycin
(Most vestibulo and nephrotoxic)
BINGI at BATO

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8
Q

Aerobic gram positive bacterial coverage of aminoglycosides?

A

KEEP PSP
Kleb. Ecoli. Enterobacter. Proteus.
Providencia. Serratia. Pseudomonas.

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9
Q

Bactericidal aminoglycoside to 30s subunit as second line drug for MDRTB?

A

Amikacin
Narrowest therapeutic window
“Liit mo Amy pati TV mo”

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10
Q

Bactericidal aminoglycoside to 30s subunit used for TB, tularemia, bubonic plague, brucellosis?

A

Streptomycin

Bubo the rat, Bruce the cow, Tulla the rabbit

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11
Q

Streptomycin teratogenic effect?

A

Congenital deafness

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12
Q

Bactericidal aminoglycoside to 30s subunit used for hep enceph and for bowel prep in elective surgeries?

A

Neomycin
-cause NMB like curare (reversed by ca gluc, neostigmine)
Kanamycin (most ototoxic) “mag-oto Kana!” while Genta and Tobra (most vestibulo and nephrotoxic) “gentle sobra Ni Vee”

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13
Q

Bactericidal aminoglycoside to 30s subunit used for drug-resistant gonorrhea?

A

Spectinomycin

“Spec spec” gonorrhea

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14
Q

Enhanced ototox if combined with?

A

Cisplatin and loop diuretics

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15
Q

Tetracycline MOA?

A

TeT

Block aTTachment to T-rna

16
Q

Bacteriostatic, bind to 30s, used for mycoplasma, chlamydia, rickettsia, vibrio?

A

Tetracycline

17
Q

Tetracycline teratogenic effect?

A

Discoloration of tooth enamel

“Teeth-tracyline”

18
Q

What should not be taken with tetracycline because the drug decreases its absorption?

A

Milk

Calcium will bind to tetracycline instead of absorption in the GIT

19
Q

DOC for MDR Malaria prophylaxis?

A

Doxycycline

20
Q

Bacteriostatic protein synthesis inhibitor that bind to 50s, used for meningitis (strep, h.inf, neisseria)?

A

Chloramphenicol

Backup drug for salmonella, rickettsia, bacteroides

21
Q

Effect of chloramphenicol on the fetus?

A

Gray baby syndrome
Dec RBC, cyanosis and CV collapse
Ashen gray skin

22
Q

Bacteriostatic, binds to 50s, used for CAP, Pertussis, Diphtheria and Chlamydia?

A

Erythromycin (Macrolides)

Azith, Clarith

23
Q

All macrolides inhibit CYP450 except

A

Azithromycin

Highest Vd, slowest elimination (given OD only)

24
Q

Macrolide AE?

A

Torsades de Pointes (long QT)

Cholestatic hepatitis

25
Q

What is used if (+) macrolide resistance?

A

Telithromycin

“Macrowave and Telivision!”

26
Q

Bacteriostatic, bind to 50s, used for ANAEROBIC infections? Also for PCP and toxoplasmosis

A

Clindamycin - anaerobes ABOVE diaphragm

Metro below

27
Q

Most common AE of clindamycin?

A

Pseudomembranous colitis (Clostridium difficile)

28
Q

Used for drug resistant infections like VRSA and MRSA?

A

Linezolid

Cause serotonin syndrome

29
Q

BacteriCIDAL bind to 50s, also for VRSA MRSA?

A

Quinupristin Dalfopristin
(Streptogramin)
AE: Arthralgia myalgia syndrome

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