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Pharma > Antifungals > Flashcards

Antifungals Flashcards

1
Q

Fungicidal polyene used for systemic fungal infections (aspergillus, blastomyces, candida)?

A

Amphotericin B

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2
Q

Amphotericin common AE?

A

Renal tubular acidosis with Mg and PO4 wasting

Infusion reaction

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3
Q

How to prevent infusion reaction caused by amphotericin B? Chills, fever, muscle spasm, hypotension

A

Slow rate of infusion

Give antihistamine

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4
Q

Fungistatic pyrimidine antimetabolite that is converted to 5-FU which inhibits thymidylate synthase?

A

Flucytosine

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5
Q

What enzyme keeps flucytosine inside fungal cells? What enzyme converts it to 5-FU?

A

Permease (low levels in mammals) - leads to accumulation

Cytosine deaminase - to 5-FU

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6
Q

DOC for granulomatous foot fungal infection (Madura foot)?

A

Flucytosine

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7
Q

Azole that blocks conversion of lanosterol to ergosterol, not able to form membranes. Often used for dermatophytosis (tinea)?

A

Ketoconazole

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8
Q

Side effect of ketoconazole?

A

Gynecomastia (some drugs produce awesome knockers)

Potent CYP450 inhibitor (cyberkids)

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9
Q

Azole used for candidiasis, crytococcal meningitis and for coccidiomycosis?

A

Fluconazole

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10
Q

Cryptococcal infections at what CD4 level?

A

CD4 < 200 (like P. jiroveci)

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11
Q

Esophageal candida at what CD4 level?

A

CD4 < 500

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12
Q

Azole for sporotrichosis (rose gardener’s disease)?

A

Itraconazole (I try gardening)

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13
Q

Echinocandin used for disseminated and mucocutaneous candidiasis? Also for salvage therapy for invasive aspergillosis

A

Caspofungin

Casper - Salvage and disseminate

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14
Q

Azole that interferes with microtubule function used for dermatophytosis, accumulates in keratin, also a CYP450 inducer?

A

Griseofulvin

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15
Q

Griseofulvin contraindicated in?

A

Porphyria

“Greasy vampires”

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16
Q

Squalene oxidase inhibitor that interfere with ergosterol synthesis?

A

Terbinafine

“Ergo SQUA-TER”

17
Q

Polyene binding to ergosterol to form artificial spores used for esophageal candidiasis, available in swish and swallow preparations?

A

Nystatin

18
Q

Topical azole for seb derm, pityriasis versicolor?

A

Clotrimazole

Pharma (27 decks)

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