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Pharma > Antiprotozoals > Flashcards

Antiprotozoals Flashcards

1
Q

Antimalarial DMARD used for non-falciparum malaria? Considered a blood schizonticide

A

Chloroquine

Hydroxychloroquine

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2
Q

Chloroquine MOA?

A

Prevent polymerization of heme into hemozoin

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3
Q

DOC for chloroquine-resistant malaria and for severe falciparum malaria?

A

Quinine

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4
Q

DOC for pregnant patients with malaria?

A

Quinine

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5
Q

Quinine AE?

A

Blackwater fever
Cinchonism
Hemolysis in G6PD

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6
Q

Triad of blackwater fever, the severe complication of falciparum malaria?

A

Intravascular hemolysis
Massive hemoglobinuria
Acute renal failure

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7
Q

Other diseases that present with black urine?

A

Alkaptonuria

Porphyria

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8
Q

Tissue schizonticide used for radical cure of P. vivax and ovale malaria? Also a gametocide

A

Primaquine

Eradicates hypnozoites in the liver, prevent relapse

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9
Q

DOC for MDR malaria chemoprophylaxis?

A

Doxycycline

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10
Q

Antimalarial that is cardiotoxic (prolongs both PR and QT interval)?

A

Halofantrine

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11
Q

DOC for uncomplicated falciparum malaria in the Philippines?

A

Artemether-Lumifantrine (Co-Artem)

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12
Q

In summary, DOC for chloroquine resistant? MDR?

A

Resistant: Mefloquine, Malarone
MDT: Doxycycline - 4 days before, during the stay up to 4 weeks after departure

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13
Q

DOC for asymptomatic cyst carriers of Entamoeba histolytica?

A

Diloxanide furoate (luminal amoebicide)

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14
Q

Tissue amoebicide used as backup drug for severe intra and extraintestinal amebiasis?

A

Metronidazole

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15
Q

Backup drug for amebiasis if metronidazole cannot be used?

A

Emetine

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16
Q

Luminal amebicide for mild to moderate intestinal amebiasis used with metronidazole? Cause thyroid enlargement and peripheral neuropathy

A

Iodoquinol

17
Q

DOC for severe intestinal and extraintestinal amebiasis?

A

Metronidazole

Also used in Giardiasis and Trichomoniasis

18
Q

DOC for cryptosporidiosis at CD4<200?

A

Nitazoxamide

“Nitatago (crypts)”

19
Q

DOC for prophylaxis and treatment of pneumocystosis?

A

Co-trimoxazole

Recommended at CD4<200

20
Q

Backup drug for prophylaxis and treatment of pneumocystosis?

A

Pentamidine

21
Q

Pentamidine effect on Respiratory system?

A

Respiratory stimulation followed by depression

22
Q

DOC for prophylaxis and treatment of Toxoplasmosis?

A

Pyrimethamine-Sulfadiazine

23
Q

First line drug for early-stage West African sleeping sickness (T. gambiense) and Kalaazar?

A

Pentamidine

does NOT cross BBB

24
Q

DOC for advanced West African sleeping sickness?

A

Eflornithine

25
Q

Treatment of hemolymphatic stages of East African sleeping sickness (T. rhodosiense)?

A

Suramin

26
Q

DOC for East African sleeping sickness?

A

Melarsoprol

Crosses BBB

27
Q

DOC for Chagas disease?

A

Nifurtimox

“Tiyaga mo in FURness”

28
Q

DOC for LeiSSSSHmaniasis?

A

Sodium stibobluconate

Pharma (27 decks)

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