Heart Failure

Question 0

MOA of Digoxin?

Common AE?

Answer 0

Inhibit NaKATPase, keep Na in, keep Ca intracellular

Narrow TI, arrhythmia, visual changes (BOV, halos, altered colors)

Question 1

Cardiac glycoside used in HF to inc contractility?

Answer 1

Digoxin

Question 2

Contraindication of Digoxin?

Drug to counter?

Answer 2

Renal insufficiency
May dec K, inc arrhythmogenesis
As well as hypoMg and hyperCa

Antiarrhyth: Propanolol

Question 3

Other drugs that worsen Digoxin toxicity?

Answer 3

Loop diuretics, thiazides - hypoK

Vomiting - hypoMg

Question 4

Diuretic of choice for HF to decrease pulmo congestion and peripheral edema?

Answer 4

First-line - Furosemide, AHF

Spironolactone, eplerenone - long term, for chronic HF

Question 5

Used to decrease salt and water retention and vascular resistance? First line for chronic HF

Answer 5

ACEI - dec ventricular remodeling

ARB

Question 6

Beta 1 selective agonist only for acute HF?

Answer 6

Dobutamine / Dopamine

Not for chronic: Tolerance, arrhythmogenic

Question 7

Beta blockers that reduce progression of CHF?

Answer 7

Carvedilol. Labetalol. Metoprolol.

Chronic Leart Mailure

Question 8

Increase cAMP by inhibiting breakdown to AMP?

Answer 8

PDE inhibitors

Inamnirone, Milrinone

Question 9

Drugs shown to improve survival in HF?

Answer 9

ACEI
BB
Aldosterone antagonists