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Pharma > Antivirals > Flashcards

Antivirals Flashcards

1
Q

Anti-herpes drug used for HSV-1,2 and VZV infections?

A

Acyclovir

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2
Q

Acyclovir activity dependent on this enzyme?

A 
Thymidine kinase (TK)
Activate drug to inhibit DNA polymerase
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3
Q

Antiviral that inhibits DNA polymerase causing chain termination, used for CMV, HSV-1,2 and VZV infections?

A

Gancyclovir

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4
Q

Gancyclovir AE?

A

Leukopenia, Thrombocytopenia

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5
Q

Antiviral for CMV retinitis (MCC of blindness in ICC)?

A

Cidofovir

Active against HSV even without thymidine kinase

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6
Q

Antiviral that binds to pyrophosphate binding site, also used for CMV retinitis and HSV in ICC?

A

Foscarnet

FOScarnet = pyroFOSphate analog

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7
Q

Foscarnet AE?

A

Nephrotoxic

Hypocalcemia

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8
Q

HAART composed of?

A

2 NRTIs and 1 protease inhibitor

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9
Q

Nucleoside reverse transcriptase inhibitor (NRTI) that prevents maternal-fetal HIV transmission?

A

Zidovudine

“Zito ka lang! (Dito)”

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10
Q

Zidovudine AE?

A

Lactic acidosis

Hepatic steatosis

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11
Q

NNRTI also used for HIV?

A

Delavirdine

No phosphorylation needed to activate drug

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12
Q

Examples of NNRTI?

A

Never Ever Deliver
Nevirapine
Efabirenz
Delavudine

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13
Q

Protease inhibitor used for HIV that causes hypergly, insulin resistance, hyperlipidemia and fat redistribution?

A

Indinavir
Also cause acanthosis nigricans
“Navir tease a proTEASE”

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14
Q

Fusion inhibitor used for HIV?

A

Enfuvirtide

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15
Q

Enfuvirtide MOA?

A

Bind to gp41, prevent fusion of viral and cellular membranes

“En-fuse”

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16
Q

CCR5 receptor antagonist that block viral attachment also used for HIV infection?

A

Maraviroc

17
Q

Anti-influenza that is also used for Parkinsonism?

A

Amantadine

Influenza A only

18
Q

Amantadine causes what effect on the skin?

A

Livedo reticularis

Cerebellar dysfunction

19
Q

Anti-influenza that inhibits neuraminidase used to shorten duration of symptoms of and is the DOC for influenza A and B?

A

Oseltamivir

20
Q

DOC for HBV infection?

A

Interferon alpha + Lamivudine

21
Q

DOC for HCV?

A

Interferon alpha + Ribavirin

22
Q

Lamivudine, coupled with HBV and HIV co-infection, can increase the risk of?

A

Pancreatitis

23
Q

MCC of viral URTI?

A

RSV

24
Q

Antiviral that blocks RNA polymerases used for HCV and RSV?

A

Ribavarin

25
Q

Ribavarin AE? What is avoided with early administration of the drug?

A 
Hemolytic anemia (positive Coombs)
West nile, Ebola virus

Pharma (27 decks)

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