Antidepressants

Question 1

First line drug for MDD?

Answer 1

Fluoxetine - block serotonin reup

Backup drug: Imipramine - block NE reuptake (TCA)

Question 2

Three C’s of TCA overdose?

Answer 2

Coma
Convulsions
Cardiotoxicity

Question 3

Toxic and lethal dose of TCA?

Answer 3

Toxic 7mg/kg (75mg/tab 7 tabs)

Lethal 15mg/kg (75mg/tab 14 tabs)

Question 4

Treatment of TCA overdose?

Answer 4

Sodium bicarbonate - for cardiotox
Activated charcoal
BZ for seizures
IVF for hypotension

Question 5

Most common antidepressant that causes priapism? Block 5HT2, make serotonin available to 5HT1 (Antidepressant)

Answer 5

Trazodone

Question 6

Two TCAs that lower seizure threshold

Answer 6

Amoxapine

Bupropion

Question 7

Antidepressant that stimulates appetite, lead to weight gain?

Answer 7

Mirtazapine (MAY TAZA PA, KAIN PA)

Question 8

Antidepressant that cause serotonin syndrome with SSRI?

Answer 8

Phenelzine/Selegiline

Question 9

Phenelzine + ___ will cause hypertensive crisis

Answer 9

Cheese (tyramine)

Question 10

Symptoms of Serotonin Syndrome?

Answer 10

FATCHD

Fever, Agitation, Tremors, Clonus, Hyperreflexia, Diaphoresis