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Pharma > Antiseizure > Flashcards

Antiseizure Flashcards

1
Q

Anticonvulsant drug that blocks Na channels used for GTC? Is a potent inducer of CYP450

A

Phenytoin

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2
Q

Common side effect of Phenytoin?

A

Gingival hyperplasia (NaPaCapangit)
Hirsutism
Fetal hydantoin syndrome*
Megaloblastic anemia

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3
Q

Anticonvulsant drug which is also the DOC for trigeminal neuralgia?

A

Carbamazepine

Block Na channels and glutamate release

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4
Q

Branched chain fatty acid Anticonvulsant drug used for absence and GTC?

A

Valproic acid (fatty ACID)

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5
Q

Valproic acid AE?

A

Neural tube defects - spina bifida
GI distress
Hepatotoxic
Contraindicated in pregnancy

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6
Q

Preferred antiseizure drug for children and pregnant women?

A

Phenobarbital (Phenobarbiedoll) -

Also for Gilbert’s hyperbil

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7
Q

Cyclic ureide anticonvulsant DOC for absence seizures?

A

Ethosuximide
(Block Ca channels in thalamus)
But if absence+GTC - Valproic acid “ValEt”

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8
Q

DOC for status epilepticus?

A

Diazepam (may also use Lorazepam)

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9
Q

DOC for infantile spasms?

A

Clonazepam

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10
Q

DOC for neuropathic pain? Postherpetic - VZV

A

Gabapentin/Pregabalin

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11
Q

Anticonvulsant drug known to cause Steven Johnsons?

A

Lamotrigine

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12
Q

SJS vs TEN?

A

SJS - 2 or more mucosal surfaces, dermoepidermal junction

TEN - more than 30% BSA involved

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13
Q

Anticonvulsant drug for juvenile myoclonic epilepsy?

A

Levetiracetam

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14
Q

Levetiracetam contraindicated in patients with?

A

Schizophrenia - exacerbate psychosis

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15
Q

Anticonvulsant drug with most MOA, most toxicities, used for Lennox Gestaut and West Syndrome?

A

Topiramate

“Most TOP artist annie Lennox in the West america”

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16
Q

Triad of Lennox Gestaut?

Triad of West?

A

LGS: 1. Seizures 2. Developmental delay 3. Behavioral problems
West: 1. Infantile spasm 2. Developmental regression 3. EEG hypsarrhythmia

17
Q

First line Anticonvulsant drug for mania?

A

Valproic acid

18
Q

Anticonvulsant drug for migraine?

A

Grabe Pare Takit!

Gabapentin, Phenytoin, Topiramate

19
Q

Ethosux AE?

A

EFGH

Ethosux - Fatigue GI Headache

20
Q

Gabapentin also used for?

A

Also for migraine and allodynia (pain with usual painless objects)

21
Q

For prophylaxis of status epilepticus?

22
Q

Short acting BZD?

A

TOM
Triazolam
Oxazepam
Midazolam

Pharma (27 decks)

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