Antibiotics: Nuc Acid Synthesis Inhibitors Flashcards
Sulfonamide competitive inhibitor of what enzyme?
Trimethoprim?
Sulfo - dihydropteroate synthase (static) NOT found in mammals
Tri - dihydrofolate reductase (cidal)
“Sulfo-Static FoRed”
Sulfonamides classification into short intermed and long acting
Short - sulfaSoxazole
Intermed - intermetiate - sulfaMEThoxazole
Long - sulfaDOXine
Tagal maging doc!
Sulfonamide used for burn infections?
Silver sulfadiazine
Silver sulfadiazine AE?
Acute hemolysis in G6PDD
SJS TEN
Bactericidal sulfonamide used for UTI, P.jiroveci pneumonia, toxoplasmosis, typhoid, shigellosis?
Co-trimoxazole
What CD4 count in AIDS favor p.jiroveci?
< 200
FQ inhibit what enzyme in DNA synthesis?
DNA gyrase in gram neg (unable to relax supercoiled DNA)
Topoisomerase in gram pos (unable to separate replicated DNA)
What exhibits postantibiotic effect?
Flouroquinolone
Aminoglycoside
First gen Flouroquinolone highly protein bound, stay in blood, used for UTI but no longer used?
Nalidixic acid
Second gen bactericidal Flouroquinolone for UTI, atypical pneumonia and second line for TB?
Ciprofloxacin
Oflox. Norflox
Ciproflox AE?
Tendinitis, tendon rupture
GI distress
Flouroquinolones hurt attachment to bones
Third gen Flouroquinolone for atypical pneumonia (myco, chlamyd, legionella)?
Levofloxacin
Levoflox AE?
Tendinitis QT prolongation (Torsades)
Fourth gen Flouroquinolone with broad spectrum activity against gram pos, neg, anaerobes?
Moxifloxacin
Bactericial drug against anaerobic infections BELOW the diaphragm?
Metronidazole
Also for trichomonas and gardnerella vaginitis
