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Pharma > Hyperlipidemia and Prostaglandins > Flashcards

Hyperlipidemia and Prostaglandins Flashcards

0
Q

Raises TG and VLDL?

A

Alcohol

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1
Q

Hyperchylomicronemia associated with?

A

Acute pancreatitis

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2
Q

Reversible HMG Coa reductase inhibitor?

A

Simvastatin

“Simple lang to reverse”

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3
Q

MOA of simvastatin?

A

Decrease cholesterol synthesis
Increase LDL uptake in the liver by inc LDL receptors
Overall dec LDL levels

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4
Q

Why are statins used in ACS?

A

Stabilize plaque

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5
Q

Simvastatin AE?

A

Hepatotox.
GI distress.
Myopathy.
Rhabdomyolysis.

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6
Q

Statins Enhance risk of rhabdo and myopathy if given with?

A

Fibrates

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7
Q

When is the peak of cholesterol synthesis?

A

At night. Give statins ODHS.

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8
Q

How much of bile acids are reabsorbed? Returned back to?

A

90%

Enterohepatic circulation

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9
Q

Bile acid binding resin for hypercholesterolemia and pruritus in cholestasis?

A

Cholestyramine

Also for digitalis toxicity

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10
Q

AE Cholestyramine?

A

Constipation. Bloating. Gritty taste. Steatorrhea. Malabsorption.

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11
Q

Treat cholestyramine-induced constipation with?

A

Fiber supplements

Psyllium

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12
Q

MOA of bile acid binding resins?

A

Bind bile acids

Prevent reabsorption, increase use of hepatic cholesterol to synthesize new bile acid

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13
Q

Effect of BABR on LDL TG VLDL?

A

Modest decrease in LDL

Little or no effect on TG and VLDL

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14
Q

Where is cholesterol absorbed?

A

Jejunum
Via NPC1L1 transporter
Same transporter for physosterol

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15
Q

Selective inhibitor of NPC1L1 transporter to dec cholesterol absorption?

A

Ezetimibe

Used in cholesterolemia and physosterolemia

16
Q

Ezetimibe AE?

A

Simvastatin + fibrates - myopathy and rhabdomyolysis

Simvastatin + ezetimibe - hepatotoxicity - synergistic in lowering LDL

17
Q

Cholesterol analog, takes the place of cholesterol, dec absorption?

A

Sitosterol

AE: GI upset. Bloating

18
Q

Most effective to inc HDL, reduce TG and VLDL?

A

Niacin

19
Q 
Effect on lipid profile of:
Statins
Fibrates
Nicotinic acid
Niacin
A

Statins dec LDL
Fibrates dec TG
Nicotinic acid inc HDL
Niacin dec VLDL

20
Q

Niacin AE?

A

Flushing
Pruritus
Acanthosis nigricans
GI irritation

21
Q

Pre treatment with this reduces flushing in Niacin?

A

Aspirin or NSAIDs

22
Q

Contraindication of Niacin

A

PUD - may worsen

“NIce! Dala ka PUDs!”

23
Q

Drugs that cause flushing?

A

VANC

Vancomycin. Adenosine. Niacin. CCB.

24
Q

Activate PPAR alpha, increase synthesis of lipoprotein lipase, dec TG?
DOC for hyperTG

A

Gemfibrozil (Fibrates)

25
Q

Fibrates inc expression of apoproteins:

A

Apo A1
Apo A2
To inc HDL levels

26
Q

Fibrates at risk for what stones?

A

Cholesterol gallstones

27
Q

Drugs used for the following:
Primary hyperchylomicronemia
Dec LPL and Apo C-II

A

Low fat diet
Niacin + fibrates
To dec TG

28
Q

Familial hypercholes

A

Statins - first line to dec LDL

Plus niacin and ezetimibe

29
Q

PGE1 analog that is used for PUD, prevention of NSAID induced bleed but is also an abortifacient?

A

Misoprostol
Activate EP receptors
Inc HCO3 and mucus secretion

30
Q

Misoprostol causes what sequence?

A

Mobius sequence (teratogenic)

31
Q

PGE1 analog to maintain patency of PDA?

A

Alprostadil

“open - Al Fresco”

32
Q

PGE2 analog for cervical ripening? But also an abortifacient

A

Dinoprostone

33
Q

Low/high concentrations of dinoprostone relax/contract uterus?

A

Low contract

High relax

34
Q

PGF alpha analog for post partum hemorrhage?

A

Carboprost

WOF bronchoconstriction

35
Q

PGF 2 alpha analog for glaucoma?

A

Latanoprost

36
Q

PGI2 analog for pulmo hypertension? Reduce platelet aggregation in dialysis machines

A

Epoprostenol

“EPULMO”

Pharma (27 decks)

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