Opioid Antagonists Flashcards
Opioids with shortest half life? Longest half life?
Shortest - Remifentanil 3-4mins
Longest - Buprenorphine 4-8hours
Function of opioid receptors?
Mu “Mabagal huminga” (Respiration)
DelTa “Tolerance”
Kappa “Konstipation”
Full agonist opioid analgesic (Mu) that exerts hemodynamic effects on pulmonary circulation? Used for severe pain, chest pain in MI
Morphine
Miosis, Ortho hypo, Resp depression (Mu), Pain relief, His release, ICP increase, Nausea, Euphoria
Most potent full agonist opioid analgesia? Used in breakthrough cancer pain and severe chronic pain (as lollipop)
Ohmefentanyl (OH MY FENTANYL)
18,000 times more potent
Opioid of choice for pancreatitis? Mu and Kappa
Meperidine
no biliary spasm
Meperidine fatal if combined with?
Selegiline
Meperidine cause serotonin syndrome if combined with?
MAOI
SSRI
Opioid partial agonist also used for cough suppression?
Dextromethorphan
decreased sensitivity of cough receptors
Opioid analgesic that causes drug induced hyperthyroidism? Investigated as novel treatment of leukemia
Methadone
Opioid analgesic used for post herpetic neuralgia and DM nephropathy?
Hydrocodone
Opioid analgesic withdrawn due to fatal cardiotoxicity? Group 1C
Propoxyphene
Commonly used in suicides
Opioid analgesic that reduce craving for alcohol? Effects are resistant to naloxone reversal
Buprenorphine
“Bukas Pre! Inom tayo”
Opioid antagonist for opioid overdose?
Naloxone
Tramadol contraindicated in patients with?
Epilepsy
Can produce seizures
Opioid overdose triad?
PCR
Pupillary constriction
Coma
Respiratory depression
