Anti-Mycobacteria

Question 0

Isoniazid MOA?

Answer 0

Inhibit mycolic acid synthesis

Bactericidal

Question 1

Nicotinic acid derivative used for TB?

Answer 1

Isoniazid

Question 2

Isoniazid AE?

Answer 2

Peripheral neuropathy (Prevented by vit B6), Hepatotoxic
Drug induced lupus HIPP
INH Injures Neurons and Hepatocytes

Question 3

Rifampicin MOA?

Answer 3

Inhibit DNA-dependent RNA polymerase

Bactericidal

Question 4

Rifampicin AE?

Answer 4

4 R's
RNA polymerase inhibitor
Red orange urine
Rapid resistance
Revs up (inducer) CYP450

Question 5

Butanol derivative anti-TB?

Answer 5

Ethambutol

Question 6

Ethambutol MOA?

Answer 6

Inhibit arabinosyl transferase. Prevent synthesis of arabinogalactan needed in mycobacterial cell wall

Question 7

Ethambutol AE?

Answer 7

Red green color blindness
Retrobulbar neuritis
Retinal damage
Always perform baseline ophtha exam (ishihara)

Question 8

Most hepatotoxic anti-TB?

Answer 8

Pyrazinamide
Iso a Red Pyre!
Iso < Rif < Pyra

Question 9

Pyrazinamide MOA?

Answer 9

Unknown.
Bacteriostatic!
But can be cidal in actively dividing mycobacteria

Question 10

Pyrazinamide AE?

Answer 10

Hyperuricemia

Sterilizing agent

Question 11

Aminoglycoside used for TB?

Answer 11

Streptomycin

Bind to 30s, cidal

Question 12

Streptomycin AE?

Answer 12

Ototoxicity

Strep - tenga

Question 13

Sulfone that inhibit folate synthesis used for leprosy?

Answer 13

Dapsone

Most active drug vs M.leprae

Question 14

Dapsone AE?

Answer 14

Methemoglobinemia

Treat with methylene blue

Question 15

Phenazine dye used for dapsone resistant lepromatous leprosy?

Answer 15

Clofazimine

Question 16

Treatment for atypical PTB?

Answer 16

Azith, Clarith

with Ethambutol

Question 17

Prophylaxis for atypical PTB?

Answer 17

Clarith or azith

For patients with CD4 < 50