Parkinson's disease

Question 1

Loss of which neurotransmitter is seen in Parkinson’s disease?

Answer 1

Dopamine

Question 2

Braak staging of Parkinson’s

Answer 2

.Initially develops in olfactory nucleus/lower brainstem
.Higher brainstem
.Substantia nigra
.Mesocortex and thalamus
.Entire neocortex

Question 3

Dopaminergic anti-Parkinsonism drugs often stimulate which dopamine receptors?

Answer 3

D2

Question 4

Why is L-DOPA given and not dopamine?

Answer 4

Dopamine does not cross the BBB. L-DOPA does and is then converted to dopamine once inside the brain

Question 5

Which of the following is an ergot-derived dopamine agonist?
a. Pramipexole
b. Ropinirole
c. Bromocriptine
d. Rotigotine

Answer 5

c. Bromocriptine

Question 6

Pramipexole has preferential affinity for which dopamine receptor?

Answer 6

D3

Question 7

Ropinirole has preferential affinity for which dopamine receptor?

Answer 7

D2

Question 8

Selegiline is an irreversible inhibitor of which enzyme?

Answer 8

MAO-B

Question 9

Anti-muscarinic agent use in Parkinson’s disease

Answer 9

May help to improve tremor and rigidity, no effect on bradykinesia