Anti-Diabetic Agents: Med Chem

Question 1

What are the two sources of glucose in the body?

Answer 1

.Diet
.Liver

Question 2

Glucose that does not enter circulation is stored in the _______ as _____________

Answer 2

Liver. Glycogen.

Question 3

Insulin performs what two main functions?

Answer 3

.Inhibits glucose synthesis
.Aids in glucose uptake in the muscles

Question 4

Which is the only GLUT transporter that is insulin sensitive?

Answer 4

GLUT4

Question 5

90% of glucose is usually reabsorbed at this stage in normal patients

Answer 5

Urinary excretion

Question 6

What are the two types of incretins?

Answer 6

.GLP-1
.GIP

Question 7

Where are incretins secreted?

Answer 7

GI tract

Question 8

DPP-4 inhibitors MOA

Answer 8

Increase the half life of incretins by inhibiting DPP-4 action, which is breaking down incretins

Question 9

Protein kinase C (increases/decreases) in the presence of increased glucose levels

Answer 9

Increases

Question 10

Insulin secretagogues MOA

Answer 10

Act on pancreatic beta cells to stimulate insulin production

Question 11

Insulin sensitizers MOA

Answer 11

Makes tissue more sensitive to the action of insulin. Opposite of insulin resistance

Question 12

Insulin most often exists as
a. Monomers
b. Dimers
c. Hexamers

Answer 12

b. Dimers

Question 13

Larger insulin molecules have a (shorter/longer) duration of action

Answer 13

Longer