Hormone Therapy in Gender Affirming Care

Question 1

First line antiandrogen for gender affirming therapy

Answer 1

Spironolactone

Question 2

Which two classes of antiandrogen medications can be used in feminized pharmacotherapy?

Answer 2

Mineralocorticoid receptor antagonists and 5-alpha reductase inhibitors

Question 3

What is a common side effect of progesterone therapy?

Answer 3

Weight gain

Question 4

How often should monitoring/labs occur to assess signs of feminization?

Answer 4

Every 3 months for 1 year, then once a year

Question 5

Common dosing of testosterone therapy in transmasculine therapy

Answer 5

100-200mg q 2 weeks

Question 6

Common adverse effect of testosterone therapy in transmasculine therapy

Answer 6

Aggression

Question 7

Why are combined oral contraceptives contraindicated in transmasculine patients?

Answer 7

Risk for VTE

Question 8

What type of oral contraceptives may be used in transmasculine patients?

Answer 8

Progesterone only

Question 9

Routine health monitoring for transmasculine patients

Answer 9

Cancer screenings (specifically breast and cervical)

Question 10

When can gender reaffirming therapy begin in adolescents?

Answer 10

After adolescent has achieved Tanner Stage 2 of pubertal development