Hypogonadism

Question 1

What is primary hypogonadism?

Answer 1

Disease of the testes

Question 2

What is secondary hypogonadism?

Answer 2

Disease of the hypothalamus or pituitary

Question 3

True or false: LH and/or FSH levels are normal or low in primary hypogonadism

Answer 3

False. They are above normal in primary hypogonadism and normal/low in secondary hypogonadism

Question 4

What are the three cardinal signs of hypogonadism?

Answer 4

Decreased libido, ED, loss of spontaneous AM erections

Question 5

True or false: Testosterone is highest in the morning

Answer 5

True. Range 300-800 ng/dL

Question 6

When is testosterone replacement contraindicated?

Answer 6

Prostate/breast cancer

Question 7

Why is oral testosterone generally avoided?

Answer 7

Poor bioavailability due to first pass metabolism

Question 8

Which formulation of testosterone is preferred because it is effective and inexpensive?

Answer 8

IM testosterone cypionate

Question 9

Counseling points for the transdermal patch

Answer 9

.Rotate site every 7 days
.Avoid showering/swimming for 3 hrs after application
.May use triamcinolone for site reactions
.Does not transfer

Question 10

Counseling points for transdermal gel

Answer 10

.Cover site to avoid transfer
.Site should not be washed or in contact with anyone for 4-6hr

Question 11

Usual dosing interval for IM testosterone

Answer 11

qw or qow

Question 12

Usual dosing interval for SQ testosterone

Answer 12

qw

Question 13

Usual dosing interval for SQ testosterone implant

Answer 13

q 3-6 months

Question 14

Usual dosing interval for intranasal testosterone gel

Answer 14

TID. 6-8 hrs apart

Question 15

Usual dosing interval for transdermal testosterone patch

Answer 15

QPM

Question 16

Usual dosing interval for transdermal testosterone gel

Answer 16

QAM