Opioids PKPD Flashcards
Pruritis associated with opioid use is the result of the release of what compound?
Histamine
What are the 5 opioid chemical classes?
Phenanthrenes
Benzomorphans
Phenylpiperidines
Diphenylheptanes
Other synthetics
Phenanthrenes
Morphine
Codeine
Hydrocodone
Levorphanol
Oxycodone
Oxymorphone
Buprenorphine
Nalbuphine
Butorphanol
Nalaoxone (antagonist)
Heroin
Benzomorphans
Pentazocine
Diphenoxylate
Loperamide
Phenylpiperidines
Meperidine
Fentanyl
Sufentanil
Alfentanil
Remifentanil
Diphenylheptanes
Methadone
Propoxyphene
Morphine is less preferred in which patient populations?
Hemodynamically unstable (histamine)
Bronchospasms (histamine)
Renal insufficiency (metabolite accumulation)
Buprenorphine MOA
Partial agonist of mu opioid receptors
Methadone is primarily metabolized by which enzyme?
CYP2B6
________ metabolizes tramadol into its active metabolite, ___________
CYP2D6, M1
What properties of fentanyl make it so potent?
High lipid solubility
Fast CNS penetration
Which type of fentanyl has the shortest half life?
Remifentanyl (3-10 mins)
Fentanyl is metabolized mainly by which enzyme?
CYP3A4, except remifentanyl
What is the purpose of naloxone in Suboxone?
Abuse deterrent
