Med Chem: Women's Health

Question 1

Primary male sex steroid

Answer 1

Androgens (Testosterone)

Question 2

Which hormone both opposes and facilitates estrogen action?

Answer 2

Progesterone

Question 3

Primary female sex steroid?

Answer 3

Estrogen (Estradiol)

Question 4

True or false: All three classes of endogenous steroids are present in both males and females

Answer 4

True

Question 5

Which is the most potent of the circulating estrogens?

Answer 5

E2 / estradiol

Question 6

True or false: Bound and unbound hormones diffuse through the plasma membrane and bind to the receptor and dimerize the receptor

Answer 6

False. Only unbound hormones

Question 7

Surge of which hormone from the pituitary gland triggers ovulation?

Answer 7

LH / luteinizing hormone

Question 8

The secretion of what hormone indicates pregnancy?

Answer 8

hCG / human chorionic gonadotropin

Question 9

True or false: Estrogen receptor antagonists are more effective in treating breast cancer than aromatase inhibitors due to their MOA

Answer 9

False. Aromatase inhibitors are more effective

Question 10

Steroidal aromatase inhibitor MOA

Answer 10

Irreversibly / covalently binds to and inactivates aromatase enzyme

Question 11

Nonsteroidal aromatase inhibitor MOA

Answer 11

Competitively inhibit aromatase

Question 12

Major side effect of clomiphene

Answer 12

Greatly induces LH surge and ovulation, resulting in twins or greater multiple births

Question 13

Why is estrogen use potentially dangerous in smokers?

Answer 13

Increased risk of VTE