Antiepileptic drugs Kinetics

Question 1

True or false: Valproic acid is a broad spectrum anticonvulsant

Answer 1

True

Question 2

VPA primarily binds to which protein?

Answer 2

Albumin

Question 3

VPA is (hepatically/renally) metabolized

Answer 3

Hepatically

Question 4

VPA is a CYP substrate and (inducer/inhibitor)

Answer 4

Inhibitor

Question 5

VPA total therapeutic trough level

Answer 5

50-100 mcg/mL

Question 6

Phenobarbital is a CYP substrate and (inducer/inhibitor)

Answer 6

Inducer

Question 7

What are the two main metabolites of primidone?

Answer 7

Phenobarbital
PEMA

Question 8

Metabolites of primidone potentiate which neurotransmitter?

Answer 8

GABA

Question 9

Phenobarbital therapeutic trough level

Answer 9

10-40 mg/L

Question 10

Primidone therapeutic trough level

Answer 10

5-12 mcg/mL

Question 11

Relationship between primidone and phenobarbital

Answer 11

Primidone is prodrug of phenobarbital

Question 12

Relationship between fosphenytoin and phenytoin

Answer 12

Fosphenytoin is prodrug of phenytoin

Question 13

Difference between fosphenytoin and phenytoin

Answer 13

Fosphenytoin is water soluble and can be infused at a much faster rate than phenytoin

Question 14

Fosphenytoin infusion rate

Answer 14

150 mg PE/min

Question 15

Phenytoin infusion rate

Answer 15

50 mg/min

Question 16

Max dose of phenytoin or fosphenytoin

Answer 16

400mg

Question 17

True or false: Carbamazepine is not a broad spectrum anticonvulsant

Answer 17

False

Question 18

CBZ is mainly metabolized by which 2 enzymes?

Answer 18

CYP3A4
CYP2C8

Question 19

CBZ is a CYP substrate and (inducer/inhibitor)

Answer 19

Inducer

Question 20

CBZ therapeutic trough level

Answer 20

4-12 mg/L

Question 21

Most common serious adverse reaction of lamotrigine

Answer 21

Rash