P9 PHARMACOLOGY

Question 1

Alendronate belongs to what type of Bisphosphonates

Answer 1

Nitrogen-containing

Question 2

Etidronate belongs to what type of Bisphosphonates

Answer 2

Non-nitrogen containing

Question 3

Indications for Nitrogen-containing bisphosphonates

Answer 3

to be taken on empty stomach with tap / filtered water 30 mins before breakfast

Question 4

MOA of Bisphosphonates

Answer 4

direct inhibition of bone resorption

Question 5

Mention some Conditions characterized by osteoclast-mediated bone resorption

Answer 5

resorption Paget disease, tumor-associated osteolysis and hypercalcemia

Question 6

ADR of oral Bisphosphonates

Answer 6

Gastric & esophageal Irritation

Question 7

ADR of IV Bisphosphonates

Answer 7

cause fever & flu-like symptoms

Question 8

rare ADR of Bisphosphonates

Answer 8

osteonecrosis of the jaw

Question 9

Denosumab MOA

Answer 9

RANKL Inhibitor ;Prevents development
of osteoclasts

Question 10

Raloxifene actions on bone

Answer 10

Estrogenic in bone (anti-resorptive

Question 11

Raloxifene actions on breast & uterus

Answer 11

Anti-estrogenic

Question 12

ADR OF Raloxifene

Answer 12

hot flushes
leg cramps
risk of blood clots (rare)

Question 13

ADR of Teriparatide & Abaloparatide

Answer 13

limb pain

Question 14

Teriparatide & Abaloparatide actions on bones

Answer 14

anabolic ; increase bone formation