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UNIT 9 MULTI-SYSTEMS > P7 PHARMACOLOGY > Flashcards

P7 PHARMACOLOGY Flashcards

1
Q

calcinneurin inhibitors

A
  • cyclosporine A
  • tacrolimus
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2
Q

cyclosporine A MOA

A

binds to cyclophilin > inhibits IL-2 , IL-6 , INF GAMMA expression&raquo_space; decrease T-cell proliferation

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3
Q

ADR of cyclosporine A

A

gingival hyperplasia , nephrotoxic , hepatotoxic

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4
Q

large rapid release of cytokines into blood from the immune cells affected by immmuno-suppression is known as

A

Cytokine release syndrome

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5
Q

QT prolongation is seen with which drug

A

tacrolimus

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6
Q

tacrolimus MOA

A

binds to FKBP&raquo_space;>decrease T-cell proliferation

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7
Q

Iatrogenic Cushing syndrome is seen as ADR of which class of drugs

A

Corticosteroids

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8
Q

MOA of corticosteroids

A

Inhibit the expression of genes responsible for IL-6 , 2,3,6 production

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9
Q

drugs that alter the oral bioavailability

A

prokintics (metaclopromide)

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10
Q

Cytokines release syndrome is associated with what drugs

A
  • muromonab
  • daclizumab
  • ATG
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UNIT 9 MULTI-SYSTEMS (24 decks)

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