P6 PATHOLOGY

Question 1

Symptoms of malaria

Answer 1

Fever, headache, nausea, vomiting, muscular pain

Question 2

Symptoms of malaria occur due to

Answer 2

schizont rupture & release of pyrogens and toxins

Question 3

2 cytokines responsible for fever in malaria

Answer 3

TNF-alpha. &. IL1

Question 4

reasons why P.falciparum causes the most severe form of malaria

Answer 4

1- infects all ages of RBCs
2- Cyto-adherence
3-production of high levels of cytokines

Question 5

Anemia seen in malaria is due to

Answer 5

severe hemolysis & suppression of
erythropoiesis

Question 6

Leukopenia seen in malaria is due to

Answer 6

margination of leukocytes

Question 7

Malarial spleen: low power photomicrograph , identify what is pointed at by the arrow

Answer 7

Phagocytic cells lining sinusoids in red pulp contain malarial hemozoin pigment

Question 8

the image is showing smear preparation of the spleen , identify what is pointed at with the red arrow

Answer 8

shows trophozoites and schizonts in RBC

Question 9

the image is showing smear preparation of the spleen , identify what is pointed at with the black arrow

Answer 9

Hemozoin pigment in a macrophage

Question 10

Gross splenomegaly with hepatomegaly
is seen as

Answer 10

portal hypertension , hypersplenism

Question 11

Microscopic image of liver infected with malaria , identify what is pointed at by the black arrow

Answer 11

Sinusoids lined by Kupffer cells with malaria pigment

Question 12

mention 2 causes of acute renal failure incase of malarial infection

Answer 12

1- blackwater fever
2- hypovolemia & shock

Question 13

blackwater fever is associated with which malaria species

Answer 13

P. falciparum

Question 14

nephrotic syndrome is most commonly associated with which malaria species

Answer 14

chronic P.malariae

Question 15

gross appearance of cerebral malaria ,
Describe what is seen

Answer 15

petechial hemorrhage in white matter

Question 15

Symptoms of cerebral malaria

Answer 15

Somnolence
Seizures
Organic psychosis
Coma

Question 16

in cerebral malaria , the CSF results will show

Answer 16

increased protein +/- increased pressure, few cells

Question 17

Low power view of brain with malaria , identify what is seen

Answer 17

ring haemorrages

Question 18

the pathology seen in the shown image is caused by

Answer 18

obstructed blood vessels in P. falciparum infection

Question 18

Identify the pathology shown in the image

Answer 18

Durck granuloma: Microglial cells form small perivascular granulomas