P6 PATHOLOGY Flashcards
Symptoms of malaria
Fever, headache, nausea, vomiting, muscular pain
Symptoms of malaria occur due to
schizont rupture & release of pyrogens and toxins
2 cytokines responsible for fever in malaria
TNF-alpha. &. IL1
reasons why P.falciparum causes the most severe form of malaria
1- infects all ages of RBCs
2- Cyto-adherence
3-production of high levels of cytokines
Anemia seen in malaria is due to
severe hemolysis & suppression of
erythropoiesis
Leukopenia seen in malaria is due to
margination of leukocytes
Malarial spleen: low power photomicrograph , identify what is pointed at by the arrow
Phagocytic cells lining sinusoids in red pulp contain malarial hemozoin pigment
the image is showing smear preparation of the spleen , identify what is pointed at with the red arrow
shows trophozoites and schizonts in RBC
the image is showing smear preparation of the spleen , identify what is pointed at with the black arrow
Hemozoin pigment in a macrophage
Gross splenomegaly with hepatomegaly
is seen as
portal hypertension , hypersplenism
Microscopic image of liver infected with malaria , identify what is pointed at by the black arrow
Sinusoids lined by Kupffer cells with malaria pigment
mention 2 causes of acute renal failure incase of malarial infection
1- blackwater fever
2- hypovolemia & shock
blackwater fever is associated with which malaria species
P. falciparum
nephrotic syndrome is most commonly associated with which malaria species
chronic P.malariae
gross appearance of cerebral malaria ,
Describe what is seen
petechial hemorrhage in white matter
Low power view of brain with malaria , identify what is seen
ring haemorrages
the pathology seen in the shown image is caused by
obstructed blood vessels in P. falciparum infection
Identify the pathology shown in the image
Durck granuloma: Microglial cells form small perivascular granulomas
