P8 PATHOLOGY Flashcards
mention the factors affecting the donor’s eligibility
- the health of the donor
- the safety , purity , quality of the blood
the age of the donor should be between
17 - 65 years
the minimum donation interval is
12 weeks
a donor who gives blood when required to family members or community is known as
family / replacement blood donor
a donor who gives blood to be stored &. re-infused when required is known as
Autologous blood donor
a donor who donates only one of their blood components through process of cell separation is known as
Apheresis donor
a person who donates unwillingly is known as
forced blood donor
Mention 4 transfusion-transmissible infectious agents
- HIV
- HBV
-HCV - Treponema pallidum
red cells can be stored up until
42 days
fresh frozen plasma & cryoprecipitate can be stored up to
up to 1 year
Platelets can be stored up to
5 days
Antibodies for group A RBC type
anti-B
Antibodies for group B RBC type
ANti- A
Antibodies for group AB RBC type
none
Antibodies for group O RBC type
anti-A & anti-B
Antigens in group A RBC
A antigen
Antigens in group B RBC
B antigen
Antigens in group AB RBC
A & B antigens
Antigens in group O RBC
None
THE ABO blood group system is related to which chromosome
Chromosome 9
THE Rh blood group system is related to which chromosome
Chromosome 1
the presence of which antigen confers Rh to Rh +
the presence of D antigen
the forward typing in pre-transfusion testing identifies
the ABO & Rh-D antigens
the back typing in pre-transfusion testing identifies
Identifies corresponding iso-hemagglutinins in the serum
importance of indirect coombs test
Screening of unexpected antibodies
Identify the pre-transfusion test shown
cross- matching test
what result of this test indicates incompatibility
Agglutination of the donor RBC
transfusion threshold for packed RBc
7 g/dl
Leukocytes induced adverse effects
febrile . non-haemolytic reactions
plasma proteins , platelets . WBCs and micro aggregates can cause what reactions
Urticarial / febrile reactions
to whom you must give washed RBCs
IgA deficient patients with anti IgA antibodies
Viable T- lymphocytes can cause what disease
graft versus host disease
Identify this immune reaction
Urticaria
for invasive procedures / surgeries , what is the platelets target
50000
Identify this procedure
Apheresis
indications for fresh frozen plasma transfusion
DIC , liver disease , hereditary coagulation disorder , warfarin therapy reversal , massive transfusion
granulocyte transfusion indications
febrile neutropenia with severe neutropenia
Allergic transfusion reaction are mediated by
IgE mediated
febrile , non-haemolytic transfusion reaction is due to
Cytokines released by Leukocytes
acute haemolytic transfusion reaction is due to
IgM , mostly due to ABO incompatibility
transfusion associated acute lung injury is manifested with
dyspnea , hypoxia & fever
acute haemolytic transfusion reaction is manifested with
Urticaria , hypotension , fever . renal failure , lumbar pain
