P6 PHARAMACOLOGY Flashcards
1
Q
DOC for treatment & prophylaxis of malaria
A
Chloroquine
2
Q
MOA of chloroquine
A
prevent conversion of heme into hemozoin»_space; heme accumulates inside plasmodium»_space;> plasmodium death
3
Q
route of administration of Chloroquine
A
PO
4
Q
ADR of chloroquine
A
- GI. Irritation
- skin rash
- peripheral neuropathy
- retinopathy
- ototoxicity
- myocardial depression
5
Q
Chloroquine contraindications
A
- liver disorders
- psoriasis
- porphyria
- retinal abnormalities
- myopathies
6
Q
forms of malaria schizonts killed by chloroquine
A
blood schizonts
7
Q
drugs that are advised not to be used with chloroquine as they decrease their absorption
A
Antacids
8
Q
Malarial drug contraindicated in pregnancy
A
primaquine
9
Q
ADR of primaquine
A
- G.I irritation
- pruritis
- methemoglobinemia
9
Q
primaquine route of administration
A
oral
10
Q
primaquine contraindications
A
G6PD def. & pregnancy
11
Q
forms of malaria schizonts killed bhy primaquine
A
liver schizonts
