P1 BIOCHEMISTRY Flashcards
mention the structural tests that are done for CRC screening
1- colonoscopy
2- double-contrast barium enema
3- computed tomographic colonography
4 - flexible sigmoidoscopy
Advantages of gFOBT
-Noninvasive
- Low cost
Disadvantages of gFOBT
Detects blood in stool, but not the cause of bleeding.
Falsa-positive & False-negative results are common
FOBT are done to
- Screen for colon cancer
- Evaluate possible causes of unexplained anemia
Identify the type of FOBT shown
gFOBT
Identify the type of FOBT shown
fecal immuno-chemical test
Identify the type of FOBT shown
Flushable reagent pads
what drugs you will ask the patient to stop taking before the test
Aspirin , corticosteroids ,NSAIDs .
what vitamin is known for giving false negative results
Vitamin C
mention at least 3 reasons behind positive test results
Bleeding from esophageal varices
Colon polyp
Colon cancer
Esophagitis
GI trauma
GI tumor
Hemorrhoids
Anal fissures
IBD
Peptic ulcer
Eating red meats within 3 days of the test can give false positive results due to
Due to the presence of heme
Eating Horseradish can give false positive results due to
due to the presence of Horseradish peroxidase
vitamin C act as inhibitors of which enzyme
the pseudo-peroxidase enzyme
Identify the test result ( positive / negative )
Positive test results
mention the 3 types of tumor markers
1- Tumor specific proteins.
2- Non-specific proteins or markers related to malignant cells.
3- Cell specific proteins overexpressed in malignant cells.
