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UNIT 9 MULTI-SYSTEMS > P3 PHARMACOLOGY > Flashcards

P3 PHARMACOLOGY Flashcards

1
Q

what neurotransmitters are inactivated by endothelium

A

Bradykinin , ADP , NE , 5HT

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2
Q

Nitric Oxide precursor

A

Arginine

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2
Q

what mediators are synthesised & released by endothelium

A

Angiotensin II , NO , ENndothelin-1 &PGI2

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2
Q

nitric oxide isoforms

A

-endothelial, neuronal, and macrophageal)

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3
Q

Nitric oxide synthase inhibitor

A

N-monomethyl-L-arginine

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4
Q

3 Vascular smooth muscle relaxation agents

A

-Nitric oxide
-Glyceryl trinitrate
- Endothelium derived relaxant factor

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5
Q

NO route of administration

A

inhaled

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6
Q

mention the PDE5 Inhibitors

A

Sildenafil, vardenafil, tadalafil

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7
Q

Riociguat belongs to which class of drugs

A

Stimulators of cGMP Signaling

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8
Q

reason why sGC stimulators & PDE5 inhibitors are not combined

A

to avoid severe hypotension

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9
Q

mention at least 2 Prostacyclin Receptor Agonists

A

-Epoprostenol
- Treprostinil
-Beraprost
-Iloprost

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10
Q

route of administration of Treprostinil

A

– oral, iv, sc, inhaled

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11
Q

Teratogenic drug that’s contra-indicated in pregnancy

A

Ambrisentan, bosentan, macitentan
(Endothelin receptor antagonists)

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12
Q

Tyrosine kinase inhibitor & its route of administration

A

Imatinib ,, Oral

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13
Q

Calcium Channel Blockers

A
  • Nifedipine
  • Amlodipine
  • Diltiazem
    -Verapamil
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14
Q

most common ADR of CCB

A

ankle edema & constipation

15
Q

appetite suppressant drugs

A

fenfluramine, phentermine, Fenphen

16
Q

what is your Loop diuretic choice incase of volume overload

A

torsemide

17
Q

Pulmonary fibrosis treatments

A

perfinidone, nintedanib

18
Q

aftereload reduction therapies for right-sided HF

A
  • Prostacyclin analogs
    -PDE5 inhibitors
  • Soluble guanyl cyclase (sGC) stimulators
19
Q

preload reduction therapies for right-sided HF

A

Diuretics

UNIT 9 MULTI-SYSTEMS (24 decks)

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