P1 PHARMACOLOGY

Question 1

main treatment for early stages of colon cancer

Answer 1

Surgery

Question 2

local treatment that uses radio-frequency , cryo-ablation is known as

Answer 2

ablation therapy

Question 3

in which local treatment substances are injected into blood to reduce their blood flow to the tumors

Answer 3

Embolisation

Question 4

use of high energy rays to destroy cancer cells is used in

Answer 4

radiation therapy

Question 5

Immunotherapy is based on which principal

Answer 5

that cancer cells have tumor antigens

Question 6

Systemic chemo advantages

Answer 6

1- treating metastasis
2- preventing metastasis

Question 7

Example of regional chemotherapy

Answer 7

haptic artery infusion

Question 8

Advantage of regional chemotherapy

Answer 8

reduced side effects on normal tissues

Question 9

chemo given before Surgery is known as

Answer 9

neo-adjuvant chemotherapy

Question 10

why is chemo given prior to Surgery

Answer 10

• to shrink tumor size

Question 11

chemo given after surgery

Answer 11

Adjuvant chemotherapy

Question 12

5-Fu route of administration

Answer 12

IV

Question 13

prodrug of 5 -FU

Answer 13

Capecitabine

Question 14

MOA of 5-FU

Answer 14

Pyrimidine antimetabolite

Question 15

Oxaliplatin route of administration

Answer 15

IV

Question 16

Irinotecan route of administration

Answer 16

IV

Question 17

Trifluridine & tipiracil route of administration

Answer 17

oral

Question 18

5-Fu targets which cell cycle

Answer 18

S phase

Question 19

which drug is given with 5-FU to enhance its efficacy

Answer 19

leucovorin

Question 20

active metabolite of 5-FU

Answer 20

FdUMP

Question 21

Early onset ADR of 5-FU

Answer 21

Diarrhoea , nausea , mucositis

Question 22

late onset ADR of 5-FU

Answer 22

BM suppression , hand foot syndrome

Question 23

hand foot syndrome is seen more frequent with

Answer 23

Capecitabine

Question 24

Capecitabine route of administration

Answer 24

orally

Question 25

severe toxicity of 5-FU is seen in

Answer 25

dihydropyrimidne dehydrogenase deficiency

Question 26

MOA of Oxaliplatin

Answer 26

DNA platinum adduct formation : DNA damage , DNA synthesis arrest & mitochondrial function alteration

Question 27

Oxaliplatin ADR

Answer 27

Peripheral neuropathy , nausea

Question 28

to which class of anti-neoplastic drugs does Irinotecan belong

Answer 28

campothecin class

Question 29

MOA of Irinotecan

Answer 29

topoisomerase-I enzyme inhibitor

Question 30

Treatment of the cholinergic syndrome that is seen with Irinotecan

Answer 30

Atropine

Question 31

Irinotecan acts on which cell cycle

Answer 31

on the S phase

Question 32

MOA of Bevacizumab

Answer 32

Angiogenesis

Question 32

ADR of Cetuximab

Answer 32

Allergic reactions

Question 33

Recombinant humanised monoclonal antibody that blocks VEGF

Answer 33

Bevacizumab

Question 34

drug that inhibit TFG alpha & EFG receptors

Answer 34

Cetuximab

Question 35

Methyl-cellulose belongs ti which class of laxatives

Answer 35

bulk forming class of laxatives

Question 36

mention 2 osmotic agents of laxatives

Answer 36

lactulose & Mg oxide

Question 37

bisacodyl belongs to which class of laxatives

Answer 37

Stimulants