P7 IMMUNOLOGY Flashcards
most important pre-transplant test
Crossmatching test
mention the 3 pre-transplant test
-HLA-TYPING
- crossmatching
- PRA
Transplantation of cells, tissues or organs between sites within the same individual e.g. skin graft.
autograft transplantation
Transplantation of organs or tissues from a donor to a non-genetically identical individual of the same species
allograft transplantation
most common type of transplant
allograft transplantation
Transplantation of an organ or tissue between 2 different species
Xenograft
a cluster of genes important in
* Immune recognition
* Signalling between cells of the immune system
HLA complex /MHC
class 1 MHC are seen on which cells
all nucleated cells
class 2 MHC are seen on which cells
Mononuclear cells (lymphocytes & macrophages )
class 1 antigens
HLA A . B . Cw
class 2 antigens
HLA DR , DQ , DP
function of class 1 HLA molecules
Antigen recognition by a cytotoxic T- lymphocyte (CD8)
explain the immune response behind Organ Transplantation Rejection
The foreign(donor’s) class I HLA are recognized by the host (recipient’s) CD8 T- lymphocytes during REJECTION
explain the immune response behind GVHD
Donor T cells attack Patient’s (recipient’s)
tissue(different HLA class II Ags)
function of HLA typing
- Paternity testing
- Prior to Transplantation to select donor
- Disease association
