P2 PATHOLOGY Flashcards
very common cause of prostatic enlargement. It is characterized by proliferation of benign stromal and glandular elements.
Benign Prostatic Hyperplasia
clinical findings of BPH
hesitancy, urgency, nocturia, and poor urinary stream .
Dihydrotestosterone(DHT) is synthesised by the action of which enzyme
the enzyme 5a-reductase, type 2
the major hormonal stimulus for proliferation in BPH
Dihydrotestosterone(DHT)
in which ZONE of the prostate does BPH always occur
the inner transition peri-urethral zone
type of epithelium lining the hyperplastic glands in BPH
lined by tall, columnar epithelial cells
The glandular lumina often contain laminated proteinaceous
secretory material known as
corpora amylacea
Identify the disorder by the shown microscopic image
BPH
in which ZONE of the prostate does carcinoma occur
the outer, peripheral zone of the gland
Identify the disorder by the shown gross image
BPH
Carcinoma of the prostate is most common in which population
- african american
-Scandinavian countries
mention the 4 pathogenesis causes for prostate carcinoma
1- androgens
2- hereditary
3-Environmental exposures
4-Acquired genetic aberrations
Describe what shown giving your diagnosis
as firm, gray-white lesions with ill-
defined margins
Diagnosis : prostate cancer
how can you differentiate between BPH & prostate cancer morphologically
glands typically are smaller than benign glands & are lined by a single uniform layer of cuboidal or low columnar epithelium which is not seen in benign cells
when prostatic tissue that is removed for carcinoma also harbors presumptive precursor lesions, it is referred to as
high-grade prostatic intraepithelial neoplasia (HGPIN)
Identify the morphology shown in the image
Perineurial invasion
