Oncology 3

Question 1

Ribociclib side effect?

Answer 1

Neutropenia

Question 2

Lapatinib mechanism of action?

Lapatinib side effect?

Answer 2

Dual blocker - EGFR/HER

SE : Cardiac toxicity, diarrhea

Question 3

Imantinib side effect?

Answer 3

Muscular cramps

Maculopapular rash

Question 4

Abiraterone side effect

given with?

Answer 4

SE : Hepatotoxicity, Hypokalemia, Fluid retention

Give with low dose prednisolone

Question 5

Enzalutamide side effect?

Answer 5

Seizures

Question 6

In melanoma what amino acid is substituted?

Answer 6

Valine substituted with glutamic acid

Question 7

Tumor evading immune elimination -methods?

Answer 7

• Antigenicity lost - loss of protein surface to be recognized by MHC
• Immunosuppressive properties - secrete TGFB, IL10
• Recruit immunosuppressive leucocytes

Question 8

Melanoma treatment?

Answer 8

Dual blockade = CTLA4 + PDL1 for 3 months then

PD1- inhibitor for 2 years!

Question 9

What immunotherapy complication is not reversible?

Answer 9

Endocrinopathies

Question 10

Cytarabine used only in?

Answer 10

Lymphoma

Leukemia

Question 11

Tumor suppressor gene is involved in what function?

Answer 11

DNA repair mechanisms - p53/BRCA

Gene deletion

Question 12

Oncogene involved in what function?

Answer 12

Gain of mutation - KRAS/BRAF

Gene mutation

Question 13

Tumor markers for screening purpose?

Answer 13

AFP - non-seminoma testicular cancer

CEA - CRC

Question 14

Typhilitis treatment?

Answer 14

Gram -ve antibiotics

Question 15

Common disease to come back during chemotherapy?

Answer 15

TB and Hep B ( Lamivudine for 12 months after commencement of chemotherapy)

Question 16

what chemotherapy causes premature menopause?

Answer 16

Alkylating agents

Question 17

What chemotherapy spares bone marrow?

Answer 17

Bleomycin
Vincristine
Cisplatin
- Vicar of Christ Cisplatins spares Bleone

Question 18

Prostate cancer cells arises from where?

Answer 18

Peripheral prostate gland

Question 19

Adjuvant radiotherapy in rectal cancer when?

Answer 19

Haemorrhagic tumour
Large rectal mass
Rectal cancer with LN positive

Question 20

FAP is due to what mutation and definition of it?

Answer 20

MUTYH (MAP) gene mutation - failure of base excision repair pathway

APC gene mutation - lots of adenomas

Question 21

Lynch syndrome is due to what mutation and definition of it?

Answer 21

MLH1 loss- promoter methylation - sporadic

MSH2/6 loss -microsatellite instability

Question 22

Mismatch repair deficiency leads to?

Answer 22

Microsatellite instability

Question 23

ctDNA function?

Answer 23

Response and any recurrence to adjuvant therapy

No use if have definitive surgical resection

Question 24

5FU requires what to increase half life?

Answer 24

Leucovorin

Question 25

VEGF inhibitor : Bevacizumab use in what type of CRC?

EGFR inhibitor : Cetuximab/Pannitumumab use in what type of CRC?

Answer 25

Right sided colon or RAF/RAS

Wild type and non-EGFR resistance

Question 26

BRAF usually in which side CRC?

RAS usually in which side CRC?

Answer 26

Right side and poorer prognosis ( midgut)
BRAF - Right and Fucked

Left side and better prognosis (hindgut)

Question 27

Irinotecan needs what enzyme?

Answer 27

UAT-181 enzyme to metabolize SN38 (active metabolite)

Question 28

Cyclophosphamide side effect?

Answer 28

Interstitial pneumonitis/pulmonary fibrosis
Severe cardiotoxicity ( Bone marrow transplant regimen)
Hemorrhagic cystitis

Question 29

Daunorubicin side effect apart from cardiac toxicity?

Answer 29

Radiation recall rash reaction - site receiving radiotherapy previously - rash erupts

Question 30

ifosfamide usage in?

side effect?

How to limit the damage?

Answer 30

Sarcoma and Mets Germ cell testicular cancer

Proximal tubule dysfunction - proteinuria/aminoaciduria/glycosuria
Increased b-2 microglobulin secretion

limit cumulative dose