Oncology 1

Question 1

2nd most common cancer and 2nd most leading cause of death from a cancer?

Answer 1

Colorectal cancer

Question 2

Colonoscopy for CRC - biopsy taken every what cm?

Answer 2

10 cm

Question 3

Screening starts if ;

• HNPCC
• FAP

Answer 3

HNPCC - 25 years old

FAP 15 years old

Question 4

Bevacizumab side effects?

Answer 4

GI fistula, HTN and VTE

Question 5

Stage 2 CRC with high risk features - what can be added as adjunt therapy?

Answer 5

Capecitabine/5-Fu

Question 6

Serrated polyps adenoma mutation?

Answer 6

CpG island methylation

Question 7

Best cancer screening test in CRC?

Answer 7

FOBT

Question 8

EGFR1 mutation causes cancer in?

Answer 8

NSCLC and CRC

Question 9

EGFR2 mutation causes cancer in?

Answer 9

Breast

Question 10

KRAS/NRAS wild type - adjunctive therapy of?

Answer 10

Cetuximab/ Panitumumab + chemo - FOLFOX/FOLFIRI

Question 11

KRAS/NRAS mutant treatment?

Answer 11

Bevacizumab + chemo- FOLFOX/FOLFIRI

Question 12

Post treatment for CRC - surveillance regimen?

Answer 12

3 monthly : CEA/ Physical Ex/ DRE +/- Sigmoidoscopy then 6 monthly for 5 years

6 monthly CT CAP for first 2 years and then annually till 5 years

Question 13

Commonest gynae malignany?

Answer 13

Endometrial cancer

Question 14

PD1 ligand expression in NSCLC importance?

Answer 14

No importance because as long a SCC NSCLC - nivolumab is very effective regardless of ligand status

Question 15

EGFR activation mutation in what population?

Answer 15

Female, Asian, Non-smoker

Question 16

EML-ALK gene rearrangement in what population?

Answer 16

Male, Asian, Non-smoker

Question 17

Commonest side effect of Erlotinib?

Answer 17

Fatigue

Question 18

Can’t receive Erlotinib if what?

Answer 18

WHO functional class > 2 = too fatigue

Question 19

Crizotinib for EML-ALK NSCLC - how many % of positive cells from FISH in order to be eligible for the therapy?

Answer 19

~15%

Question 20

Commonest side effect of Crizotinib?

Answer 20

Visual disturbance

Question 21

Commonest mutation of NSCLC?

Answer 21

KRAS mutation

Question 22

Ipilimumab can cause what devastating side effect?

Answer 22

Tumor lysis syndrome

Question 23

Best TKI for metastatic renal cell carcinoma?

Answer 23

Nivolumab + Cabozantinib

Question 24

Nivolumab is what Ig?

Answer 24

IgG4

Question 25

Platin (carboplatin) are what?

Answer 25

DNA cross-linking agents

Question 26

Abiraterone mechanism of action?

Answer 26

Inhibit CYP17 - decrease androgen biosynthesis

Question 27

Seminoma surveillance regimen?

Answer 27

AFP+ bHCG and Abd/pelvic CT every 3 months - 2 years
then 6 months - next 2 years
Annually then

Question 28

-zomib Mechanism?

Answer 28

proteasome inhibitor

Question 29

-tinib mechanism?

Answer 29

TKI inhibitor

Question 30

-ciclib mechanism?

Answer 30

cyclin kinase inhibitor