Infectious Disease 1 Flashcards

1
Q

C. difficile - high co-infection with?

A

CMV

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2
Q

Stronglyloids stercoralis co-infection with?

A

HTLV - Human T Lymphotropic virus

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3
Q

Mycosis fungoides a/w with what viral infection?

A

HTLV-2!

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4
Q

Treatment for Stronglyloides stercoralis?

A

Ivermectin and repeat after 2 weeks ( to eradicate larva stage)

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5
Q

Toxoplasmosis primary prophylaxis?

A

TMP-SMX

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6
Q

Mucormycosis treatment?

A

Liposomal Amphotericin B then posaconazole

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7
Q

Mucormycosis clinical feature?

A

Invasive mold infection like aspergillous but in rhinocerebral spread fashion - cause blindness

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8
Q

Mucormycosis a/w with what group of people?

A

DM
Immunocompromised
Covid19 patient - high steroid dose factor
Iron overload

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9
Q

Sedosporium apiospermum, profilicants treatment?

A

Voriconazole

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10
Q

Posaconazole used as prophylaxis in what group of patients?

A

AML/ HSCT

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11
Q

Why Voriconazole cant be use in ESRF?

A

Cyclodextrin component (oligosaccharides)

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12
Q

AML patients prophylaxis drugs?

A

Antifungal - posaconazole
Antiviral- aciclovir
Antibiotics - ? fluoroquinolones to reduce Febrile neutropenia

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13
Q

PJP prophylaxis indicated if what steroid dose?

A

Prednisolone > 25 mg/day > 4 weeks

Dexamethasone > 4mg

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14
Q

Only HB core antigen positive - give prophylaxis in what group of patient?

A

HSCT patients!

Rituximab therapy!

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15
Q

Most specific test for EBV?

A

Heterophile antibody - monospot

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16
Q

What part of EBV causes African Burkitt lymphoma and malignancies?

A

LMP-1 bound to CD40

17
Q

Mechanism of valganciclovir/ganciclovir?

A

Inhibit CMV DNA polymerase - suppress bone marrow - neutropenia

18
Q

Foscarnet mechanism of action?

A

Pyrophosphate analogue - inhibit DNA polymerase

19
Q

What viral terminase inhibitor for CMV in HSCT patients?

A

Letermovir

20
Q

Prophylaxis treatment in woman exposured to varicella?

A

IF < 4 days - Varicella Immunoglobulin

IF > 4 days - oral aciclovir

21
Q

Treatment of PTLD?

A

Rituximab - only in lytic stage

22
Q

Measles spread via?

A

infectious droplets

23
Q

Clinical symptoms of COVID19 mainly through what mechanism?

A

spike glycoprotein interacts with ACE2 surface receptor

-loss of ACE2 = RAAS uninhibited —-> endothelial injury/inflammatory response/coagulation cascade

24
Q

How Covid19 gain entry?

A

TMPRSS2 and ACE2 receptor

25
Q

Remdesmivir targets what of covid19?

A

Rdrp - RNA dependent RNA polymerase

26
Q

Moderna and Pfizer uses what concept?

A

Nanolipid particles containing RNA - encode of COV2 spike protein

27
Q

What monoclonal antibodies for covid19?

When recommended?

A

Bamlanivimab + Etesevimab
Alternative : Casirivimab + Imdevimab (Regeneron)

Outpatient Mild covid - at high risk of progression

28
Q

Main mode of transmission of covid19?

A

1st = Direct transmission

  • Droplet
  • Contact

Airborne transmission - aerosol - particles suspended longer on air
Indirect transmission - vehicle - clothes/objects

29
Q

Droplet vs airborne difference?

A

Droplet - particle > 5um diameter ( heavier) so shorter distance , within 1 meter

Airborne - particle < 5um diameter so longer distance, aerosol

30
Q

Which activity transmits most virus particle?

A

Sneezing

2nd is bowel evacuation

31
Q

When is covid19 infectious?

Incubation period of covid19

A

Day 0 - day 0 have symptoms till day 5 (highly infectious)

Day 0 - 10 is infectious

Incubation period is 7 days
*Every decade add 1 day