Infectious Disease 8 Flashcards
Mycobacterium marinum ( TB in water) treatment>
Moxifloxacin
Clarithromycin
Rifampicin
Lucio phenomenon caused by?
Mycobacterium leprae
- blue hemorrhagic lesion with necrotizing ulceration
What species of Aedes mosquito reduces Dengue transmission?
Wolbachia
Amphotericin B mechanism of action?
bind ergosterol membrane - altering integrity
Triazoles ( fluco/ketoconazoles) mechanism of action?
inhibit CYP450 - decreased ergosterol production
Terbinafine ( allylamines) mechanism of action?
Inhibit squalene epoxidase - decrease in lanosterol + ergosterol
Flucytosine mechanism of action?
Converted to 5-fluorouracil - incorporate into fungal RNA and inhibit protein synthesis/ thymidylate synthase