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BPT annoying facts > Deck 1 > Flashcards

Deck 1 Flashcards

1
Q

PTLD occurrence
highest in?
lowest in?

A

Highest = intestinal/ multi-organ transplant

Lowest = HSCT/ renal transplant

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2
Q

Mnx of PTLD?

A

1st line = Lower the immunosuppressant dose

2nd line = Rituximab

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3
Q

Gene responsible for EARLY onset Alzheimers?

Gene responsible for late onset Alzheimers?

Gene reduces risk of Alzheimers most?

A

early = APP gene - amyloid precursor protein

late = APOE

protective =APOE e2

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4
Q

What drugs inhibit glucuronidation?

A

Valproate

The rest all induce glucoronidation!

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5
Q

How is F8 released from vWF?

A

Thrombin activity

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6
Q

When do you start Desmopressin?

A

NA > 145
+
Urine output > 300 mls/hr for 3 hours

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7
Q

Metastatic Head and neck cancer - 1st line treatment? and 2nd line treatment?

A

1st line - 5-fluorouracil + Cisplatin

2nd line - nivolumab!

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8
Q

NUDT15 mutation causes increased side effects of what drug?

A

Azathiopurine

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9
Q

TH17 producing IL17 can be involve in what bone process?

A

Bone formation and erosion

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10
Q

2nd line therapy for ankylosing spondylitis for both Axial and peripheral Ankylosing spondylitis?

A

TNFa inhibitor and IL7 blocker

( Adalimumab, Secukinumab) -must continue for 2 years!

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11
Q

What IL promotes entheseal (enthesitis) inflammation?

What IL promotes osteoproliferation?

A

Enthesitis = IL-23

Osteoproliferation = IL-22

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12
Q

Reactive arthritis associated with what causes more severe chronic disease?

A

HLA-B27

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13
Q

When treat aortic aneurysm? electively

When license is removed in AAA?

A

AAA > 5 cm in female, > 5.5 cm in male

when AAA > 5.5cm

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14
Q

Low hepatic extraction ratio drugs?

A

NCAIDS

N- NSAIDS
CA- Carbamazepine
DI - Diazepam
S - S-warfarin ( commonest type of warfarin)

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15
Q

What protein binds to acid drug?

What protein binds to alkaline drug?

A

Albumin = Acid

Alkaline/basic = Alpha-1-Glycoprotein

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16
Q

Classes for prescribing drugs in pregnancy and means?

A 
A = Good
B1 = Limited woman taking drugs - but no animal studies or data showing it's bad

B2 = animals studies inadequate/lacking

B3 = animals studies shows damage, but unknown in human

C = Causing reversible damage in fetus

D = Damage irreversible

X = Death/lethal

17
Q

Acamprosate mechanism of action?

Indication

A

NMDA/GABA modulator

Indication - alcohol dependence = maintain abstinence
non-addictive

18
Q

Baclofen mechanism of action?

A

GABA-B Agonist

19
Q

Disulfiram mechanism of action?

A

inhibit aldehyde dehydrogenase - more side effects of alcohol

20
Q

Methadone mechanism of action?

A

mu opioid receptor agonist

K channel blocker - causes prolonged QTc

21
Q

Amitriptyline toxicity - what to give?

A

Sodium bicarbonate

22
Q

Commonest reason drug remove from market?

A

Drug induced liver injury - DILI

23
Q

Morphine act on what receptor?

A

G-coupled protein receptor ( mu receptor)

24
Q

diazepam mechanism of action?

A

GABA agonist - Voltage gated CI channel

25
Q

Base excess high in the positives means?

amount of acid needed to restore PH to normal value

A

Metabolic alkalosis
attacking compensating primary respiratory acidosis ( HCO will go up)
Cushing’s
HCI loss via vomiting

26
Q

Sweet syndrome diagnosis

Major and minor criteria?

A

Major

  1. Abrupt onset of tender nodules/plaques
  2. Dense neutrophilic infiltrate

Minor ( 2 of 4)

  1. Fever
  2. After GI/fever/malignancy/DRUG INDUCED - abx
  3. Elevated CRP/ESR
  4. Steroids responsive!
27
Q

when consider Ponticelli treatment in Membranous nephropathy?

A

(Prednisolone + chlorambucil)
-severe proteinuria > 8g + significant renal dysfunction

Otherwise CYP

28
Q

Tamoxifen in DCIS?

A

Reduce recurrence of CONTRALATERAL DCIS

29
Q

Intention to treat analysis always affect treatment in what ways?

A

Underestimate it

30
Q

H.pylori confirmation of eradication test
Abx must stop how many weeks prior to test?
PPI must stop how many weeks prior to test?

A

ABX - 4 weeks

PPI - 2 weeks

BPT annoying facts (62 decks)

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