Neurology 5 Flashcards

1
Q

Thalamus role?

Thalamus in parkinson?

A

Sensory cortex
Inhibit GABA

No more inhibition ( loss of dopaminergic neurons) = unwanted movements

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Familial CJD - mutation?

A

PRNP mutation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

CJD - what result seen in LP?

A

Protein 14-3-3

Caudate hyperintensity on MRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Progressive Bulbar palsy a/w what mutation?

A

SOD1 -glutamate toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Teriflunomide MOA?

A

inhibit dihyro-oorotate dehydrogenase - disrupts pyrimidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Glatiramer MOA?

A

Myelin protein mimicker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dimethyl fumarate MOA?

A

NF2 activator - protect neuron from oxidative stress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Alemtuzumab famous side effect?

A

Autoimmune thyroiditis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Cladribine MOA?

A

Cut off memory B cells, decrease lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Relapse remitting MS has what feature?

A

Bilateral INO

Unilateral Optic neuritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Focal impaired awareness arises from what cortex?

focal seizure = EEG finding?

A

Mesial temporal lobe - hippocampus

Anterior temporal lobe spike

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Hyperventilation can induce what type of seizure?

A

Absence seizure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which AED is non-linear kinetics?

A

Gabapentin

Phenytoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which AED is renally secreted?

A

Gabapentin

Levetiracetam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which AED is safe in pregnancy?

A

Levetiracetam

Lamotrigine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Wallerian degeneration?

A

WALL-E = distant future = degeneration distal to axon injury

17
Q

Haemotoxylin-Eosin staining for what?

A

ANCA vasculitis
Amyloid
Sarcoidosis
-all have asymmetric progressive neuropathy

18
Q

Multifocal motor neuropathy commonest presentation?

A

Wrist drop

+ve anti-GM1

19
Q

Acute MG - lung function test?

Chronic MG - lung function test?

A

PEFR (acute)

FVC ( chronic)

20
Q

IBM antibodies is what?

A

anti-NTSC1a

21
Q

what connects wernicke and broca area?

A

Arcuate fasciculus

22
Q

Hemicrania continua a/w what?

A

pituitary adenoma/prolactinoma

23
Q

MRI changes a/w Enterovirus?

A

Basal ganglia/brainstem

24
Q

Viral encephalitis complications?

A

Chronic amnesiac state

Kluver-bucy syndrome (B/L temporal lobe)

25
Q

Cranial nerves
purely motor

purely sensory

A

Sensory : 1, 2 and 8 ( I 2 sensed hunger and ATE(8)

Everything else is purely motor except 5,7,9,10

Mixed : 5,7,9,10

26
Q

What nerves passes through cavernous sinus?

A

3,4,5,6

27
Q

Ramsay Hunt syndrome means VZV reactivation where?

A

7th nerve geniculate ganglion

28
Q

7th nerve palsy at pontine due to?

7th nerve palsy at cerebellopontine angle due to?

A

Pontine - Vascular, tumour

CP angle - acoustic neuroma

29
Q

Strongest risk factor for recurrent TIA/stroke

A

Severe carotid artery stenosis

30
Q

TACI cardinal signs?

site of lesion?

A

Higher centre dysfunction
Homonymous hemianopia
Motor/sensory = 2/3 face/arm/leg

Site - ICA/ proximal MCA - M1

31
Q

PACI cardinal signs?

Site of lesion

A

DANISH signs
Dysdiadochokinesia/Ataxia/Nystagmus/Intentional tremors/Slurred speech/Hypotonia

Site - Distal MCA