Immunology 5 Flashcards

1
Q

GM-CSF - role in stem cell transplant?

A

Hit and shake bone marrow to produce more stem cells and release into bloodstream - then collect it - peripheral collection Stem cell

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2
Q

Glucocorticoids effect?

A

Neutrophilia - transient
CD4 lymphopenia
Eosinophil depletion

Inhibition of cytokines ( IL1/IFNy/TNF), prostaglandings, leukotrienes

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3
Q

6-Thiopurine from AZA - what it does?

A

Incorporate into nucleotide chain - antiproliferative effect on Lymphocytes/NK cells

Induce T cell apoptosis via Rac gene

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4
Q

Mycophenolate mechanism of action?

A

Inhibit IMDPH - so no guanine nucleotide production ( essential in T,B lymphocytes)

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5
Q

MTX inhibit Dihydrofolate reductase so?

A

So no purine (AG ) synthesis

Adenosine
Guanine

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6
Q

Cyclophosphamide causes hemorrhagic cystitis - how to prevent it?

A

MESNA hydration

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7
Q

IVIG mechanism of action?

A

Antibodies against immuno-modulatory proteins/ super-antigens + catabolism

Fc-Rn binding = recycles IgG so increases half life

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8
Q

How infection breaks immune tolerance?

A
  1. Anti-self T cells tolerised by self Ag BUT BY IMMATURE DC ( no B7)
    - infection has Antigen - trigger by DC (has B7)
  2. Molecular mimicry
    - foreign peptide SIMILAR to self-antigen but its not completely exact same. So T cell activate and attack foreign peptide ( think done good job)

but at the same time attack self ( recognise self-antigen as foreign now)

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9
Q

Coeliac disease pathogenesis?

How pseudomonas fluorescence causes coeliac disease?

A

Gliadin ( can’t be digested) - go bind TTG

TTG deamidate glutamine. so gliadine is now DAG ( deamidated gliadin)

DAG Binds to HLA DQ2/8 - Activate PFSGDS antibodies
-trigger CD4T cells/ B cells

  1. Pseudomonas enter gut mucosa and anti-PFSGDS produced and drives T cells. So molecular mimicry - trigger T cells via PFSDGS antibodies
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10
Q

Rituximab need to bind to what to initiate complement mediated killing?

A

C1q

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