Morphine Sulfate

Question 1

Morphine Class

Answer 1

CNS depressant, narcotic analgesic (C)

Question 2

Morphine Mechanism of Action

Answer 2

Binds to opioid receptors in the CNS to produce analgesia (the inability to feel pain), sedation, and euphoria.

Causes vasodilation, thereby decreasing peripheral vascular resistance

Reduces preload and afterload, thereby decreasing myocardial oxygen demand

Question 3

Morphine Indications

Answer 3

Pain (including chest pain resulting from suspected AMI and for acute pulmonary edema)

Question 4

Morphine Contraindications

Answer 4

• Hypersensitivity
• Respiratory depression
• Head Injury
• ALOC
• Hypovolemia
• MAOI’s

Question 5

Morphine Drug Interactions

Answer 5

Use with other CNS depressants will potentiate the effects of Morphine

Question 6

Morphine Precautions

Answer 6

May cause significant hypotension and respiratory depression;

Support ventilations as necessary and treat overdose with
naloxone (Narcan)

Use caution in the elderly and patients with multisystem trauma

Question 7

Morphine Onset

Answer 7

Immediate

Question 8

Morphine Duration

Answer 8

2–7 hours

Question 9

Morphine Dosage Adult

Answer 9

2–10 mg IV or 5–20 mg IM, q 5 min PRN

Question 10

Morphine Dosage Pedi

Answer 10

0.1–0.2 mg/kg IV/IM, q 5 min PRN (15 mg max dose)