Monoclonal antibodies Flashcards
The antibodies have a high…
degree of specificity. This makes them suitable for the diagnosis and treatment of disease.
Monoclonal antibodies are…
antibodies secreted by B cell clone, all identical. Also called Mabs.
B- cells that divide by mitosis do not…
produce antibodies.
The plasma cells do not…
divide.
Hybridoma cells divide by…
mitosis and secrete antibodies.
To create hybridoma cells…
a small number of plasma cells producing particular antibody are fused with cancer cells.
Mabs can be used to locate the position of…
blood clots in the body of a person with a deep vein thrombosis.
Antibodies are produced by injecting…
a mouse with human fibrin, the main protein found in blood clots.
The mouse produces many plasma cells that…
secrete antibody against fibrin.
The plasma cells are then collected from the mouse’s…
spleen and fused with cancer cells to form hybridomas.
A radioactive chemical that produces…
gamma radiation is attached to each antibody. The location can be then located using a gamma-ray camera.
Uses of Mabs in diagnosis:
- to locate cancer cells
- used to identify an exact strain of a virus or bacterium
