Enzyme Inhibitors Flashcards
Competitive Inhibitor is…
Molecule with very similar shape as enzyme’s substrate, which binds to the active site. This inhibits the enzyme’s function.
Competitive inhibitor competes for…
The active site with substrate.
Non-competitive inhibitor binds to…
Other side of the enzyme which results in the change of active site, so substrate cannot bind.
V-max means that
All the active sites are occupied.
Competitive, reversible inhibitor
If the inhibitor molecule binds only briefly to the site. It is reversible as it can be resolved by increasing the concentration of the substrate.
Non-competitive inhibitor disrupt…
The normal arrangement of H bonds and hydrophobic interactions holding the enzyme in 3D shape. This changes the active site.
Why is inhibition essential?
Metabolic reaction must be very finely controlled and balanced, so no single enzyme can be allowed to constantly produce more product.
One way of controlling metabolic reaction is…
End product inhibition
End product inhibition uses…
End product of a chain of reactions as inhibitor
(End product inhibition) as the enzyme converts substrate to product it is…
Slowed down because the end product binds to another part of enzyme and prevents more substrate to bind
(End product inhibition) as product levels fall, the enzyme is able to…
Top then up again
End product inhibition is non-
Competitive reversible inhibition
