Module 2 Formative Quiz

Question 1

Which adrenergic receptor is predominantly associated with causing vascular smooth muscle contraction

Answer 1

alpha 1

Question 2

Which is the least expected consequence of NO (nitric oxide) action on vascular smooth muscle

• Activation of myosin light chain phosphate
• relaxation
• increased intracellular Ca2+
• increased PK+

Answer 2

Increases intracellular C2+

Question 3

Which is the most reasonable explination for the presence and subsequent action of NO in smooth muscle cells?

• It is a pysical part of the plasma membrane
• it is already stored in the vascular smooth muscle cells
• When endothelial cells are activated PNMT convenrts L-arginine to NO
• it diffuses from endothelial cells into VSM

Answer 3

it dissues from endothelial cells into vascular smooth muscle

Question 4

what is the predominant cellular products of PLC beta activation

Answer 4

IP3
DAG

Question 5

Atropine is classified as a?

Answer 5

parasympatholytic

Question 6

which of the following warrants exclusion from a list of systemic responses to the fight or flight phenomena.

list: bronchodilation, positive cardiac chrontropism, increases hepatic glycogenolysis, increased threshold of reticular formation

Answer 6

increases threshold of the reticular formation

Question 7

which statment about alpha 2 receptors near exercising skeletal muscle is likely true

• They are ionotropic and can bring skeletal muscle to threshold, thereby increases strength
• their activation probably increases skeletal muscle perfusion during exercise
• they cause vascular resistance to increase

Answer 7

their activation probably increases skeletal muscle perfusion during exercise

Question 8

which statment best desribes the role of yohimbine in anesthesia

• induction and antibiotix
• induction and anaglesia
• reversal agent

Answer 8

revesal agent

Question 9

what is the adaptive sig. of bronchodilation as the predominant characterisitc / property assoaicted with sypmatheteic activation - fight or flight

Answer 9

reduced airway resistance

Question 10

It is probable / likely to have more than one GPCR on a cell membrane (of the same cell)?

Answer 10

yes

Question 11

Are you likley to find more than one ionotropic receptor on a skeletal muscle cell?

Answer 11

no

Question 12

Catecholamine-O-methyl-transferases are directly responsible for what?

Answer 12

decreasing the T1/2 of catecholamines

Question 13

which structure / organ in the body receives projections neurons from the ANS, alcks contact with a proper second projection neuron, but behaves like a modified second projection neuron

Answer 13

adrenal medulla

Question 14

which of these compounds is associated with muscarinic receptors?

Amlodipine
Atropine
Pimobendan
Vepramil

Answer 14

Atropine

Question 15

which enzyme is responsible for the degradation of circulating acetylcholine

Answer 15

pseudocholinesterase

Question 16

which NE precursor is structurally ideantical to di-hyroxylated phenylaline

Answer 16

L-dopa

Question 17

What is the appropiate NE:E ration released into the general circulation when the adrenal medulla is appropriately stimulated and the chromaffin cells degranulate

Answer 17

17:83

Question 18

identify the two predominant mechanisms / pathways that help reduce the T 1/2of IV administered catecholamines

Answer 18

hepatic CYP system and COMT / MAO’s

Question 19

which compounds are predicatably decrease cardiac contractility, HR, and increase refactory times in nodal tissues

Answer 19

competitive antagonist of Beta receptors