Module 1 Formative Quiz Flashcards
which process, regarding the elimination of a compound from a compartment best reflects that is is saturable
Michaelis-Monton kinetics
which characteristic of a neuromodulator would be best associated with an effect lasting for only a short duration
low receptor affinity
Drug X has a higher apparent Vd than drug Y. which drug (X or Y) should require a higher dose to achieve a given plasma concentration, compared to the other drug?
X
what is calcuated volue of distribution (Vd) for a 120 mg IV dose of a drug achieving a C max of 1 mg/L
120L
which type of ligand-receptor bond would correspond to the expression “highest affinity”
covalent
which molecule is least likely to be found on a list of regulatory proteins?
acetylcholine
which plasma protein functions as a chaperone for most drugs in the systemic ci rculation
albumin
which statement is best reflects/ is consistent with the expression “therapeutic index”
the ratio between dose-response beneficial and adverse effects of a particular drug
what is the major differentating factor between the terms efficacy and potency?
potency is the amount of drug required for a given response
what is the maximum response on a drug-response curve termed?
Emax
in which direction will the dose response curve of an agonist (drug x) shifts in the presence of a competitive antagonist?
to the right
which type of competitive antagonist effect on a dose-reponse curve can predictably be overcome by increasing the concentration of the agonist?
reversible competitive antagonist
what is the mechanism of action of fluoxetine?
it is a serotonin reuptake inhibitor
what is the predominant receptor class for B2 adrenoreceptors?
G protein coupled receptors
what is the predominant GABA agonist receptor class
Channel linked receptor
