Mod 4 Musculoskeletal system Anatomy of the head, neck and trunk Flashcards
What is myosin?
Myosin (thick) close to the M line
What is actin?
actin (thin) close to the Z line
How does the muscle contract with actin and myosin?
1) the myosin pulls the actin along the cross-bridges of the myosin filaments
2) the myosin filaments attach to the actin filaments and exert force for them to move (a sliding mechanism)
Muscle contraction with actin and myosin ext.
- The myosin head extends and attaches to the binding site on actin (forming the cross-bridge) also where ATP binds and converts it to ADP.
- the Powerstroke is triggered when the myosin pulls the actin towards the M line (shortening the muscle)
Ca+2 and muscle contractions?
- muscles contractions are associated with the Ca2+ levels
- tropomyosin: relaxes the muscle as it blocks the cross-bridge on actin
- Ca+ binds to troponin –> it allows the binding site
- Ca+ ions are stored in the SR and are released from the NS
- neurotrans. are released and bind to receptors depolarises the membrane of the muscle fiber.
- the impulse travels down the T-tubules and opens the Ca+ stores, calcium ions flow to the myofibrils where a muscle contraction is triggered
Actin and myosin summary?
The actin and myosin slide along with each other, the sarcomere shortens as the Z lin draws closer to the M line (shortening and then contracting the muscle).
What is the sarcoplasmic reticulum?
It is smooth endoplasmic reticulum in muscle fibres
What are myofibrils surrounded by?
Myofibrils are surrounded by sarcoplasmic reticulum and T-tubules
What does the sarcoplasmic reticulum store?
The sarcoplasmic reticulum store Ca 2+ released during a muscle contraction
What are T-tubules?
T-tubules are a part of a sarcolemma that runs between the SR –> and AP propagating down T-Tubules cause the release of Ca+ from the SR: which allows the actin and myosin to bind
What are thin filaments made of?
Thin filaments are made of actin, tropomyosin, troponin
What is tropomyosin?
Tropomyosin blocks myosin binding site in the relaxed muscle (with a protein blocking the binding site on myosin-binding sites on actin)
Troponin?
Has the binding site for Ca+, the Ca+ binds to the troponin, making the tropomyosin move away from the active sites on actin, the actin then binds to myosin to form cross-bridges (ATP)
What are thick filaments?
Thick filaments are myosin which has binding sites for ATP
Muscle contraction summary
1) AP travels down a motor neuron
2) Acetylcholine is released at the neuromuscular junction (synapse between neuron and muscle)
3) AP runs down the sarcolemma of the muscle
4) AP travels down the T-tubules
5) Ca 2+ is released from the Sarcoplasmic reticulum
6) Ca+ causes actin and myosin to bind
7) sarcomeres shorten
8) muscle contracts
What are axial muscles?
Muscles of the head and neck are in includes in the axial muscles. The muscles of facial expression, mastication, pharynx, and larynx. Muscles of the vertebral column and the thorax, abdomen and pelvis