MMB (046-a) ARTHRITIS: What Goes Wrong With Articular Cartilage

Question 1

figure illustrates components of the cartillage matrix

Answer 1

Question 2

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Question 3

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Question 4

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Question 5

Biochemical pathogenesis of osteoarthritis ?

Answer 5

Question 6

Three scenarios for cartilage injury ?

Answer 6

Question 7

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Question 8

How can mechanical stress lead to osteoarthritic changes ?
(Pathogensis) and what changes arise initially afterwards ?

Answer 8

Question 9

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Question 10

Compensatory Mechanism to antagonate cartilage damage ?

Answer 10

Question 11

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Question 12

3 Biochemichal changes in OA ?

Answer 12

Question 13

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Question 14

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Question 15

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Question 16

The vicious cycle of OA ?

Answer 16

Question 17

What determines whether OA can be reversed or not ?

Answer 17

-if the initial insult on the cartilage is removed prior to collagen fibrillation, then the cartilage restores its proteoglycan content

-Cartilage that is fibrillating has a poor capacity to repair or regenerate appropriately. This is because cartilage is avascular and lacks incoming circulatory cells (e.g. macrophages, stem cells).

Question 18

Common medication treatment used for OA in addition to analgesics ?

Answer 18

Viscosupplementation : by intra-articular injection of hyaluronan.