Microbial Pathogenesis Flashcards
What’s the basic life cycle of a pathogen?
Enter
attach
colonise
evade host immunity
produce harmful proteins
disseminate
release from host
What is a pathogen?
A pathogen is an organism which is capable of causing disease
What does exogenous mean?
External Origin
What is a commensal?
An organism that is part of the normal flora
What is pathogenicity?
The ability to cause disease
What is virulence?
The ability to cause severe disease
What subsections are microorganisms divided into?
Bacteria
Fungi
Viruses
Prions
Parasites
What is colonisation?
When microbes find a new host and start to multiply
What is an endogeneous infection?
If source of microbe is patients own flora
What is Koch’s Postulate?
The microbe must be present in every case of the disease.
It must then be isolated from the host and grown in pure culture
Put into susceptible host
Recovered from infected host
How may microbes enter the body?
Ingestion
Transplacental
Injection
Inhalation
Across mucous membrane
What is sometimes present in a prokaryotic cell?
Capsule
Fimbriae
Flagellum
Membranous Invagination
Inclusion Granules
What allows prokaryotic cells to attach to one another?
Pili (Fimbriae)
What protein in urine helps protect against UTI’s?
Tamm-Horsfall Protein
What is an example of an encapsulated infection?
Meningitis
Pneumonia
Otitis Media
Caused by over active immune response
